ArticleProceedings. Biological sciences2018
Self-limiting population genetic control with sex-linked genome editors.
Article in Proceedings. Biological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 80 citations in OpenAlex.
- Y-linked editors for invasive rodent control.Molecular biology and evolution · 2026Article
- Self-limiting population suppression gene drive design in the West Nile vector mosquito, Culex quinquefasciatus.Nature communications · 2026Article
- Sex distorter male drive for resistance-resilient population control of the human malaria vector Anopheles gambiae.Nature communications · 2026Article
- Genetic engineering for SIT application: a fruit fly-focused review.Insect science · 2026Review
- The LAST Mile: Evaluating Genetic Biocontrol as a Supplemental Tool for Eradicating Invasive Rodents on Islands.Evolutionary applications · 2026Article
- Advancing Malaria Vector Control: Insights Into Mosquito Immunity and Genetic Strategies.TheScientificWorldJournal · 2026Review
- Establishment of transgenic Drosophila suzukii lines that express phiC31 integrase and carry the sepia gene as a marker for transformation.Insect molecular biology · 2025Article
- A male-drive female-sterile system for the self-limited control of the malaria mosquito Anopheles gambiae.Nature communications · 2025Article
- Autosomally-encoded segregation distortion of sex chromosomes.Proceedings. Biological sciences · 2025Article
- Understanding the genetics of sex determination in insects and its relevance to genetic pest management.Insect molecular biology · 2025Review
- A Comparative Assessment of Self-limiting Genetic Control Strategies for Population Suppression.Molecular biology and evolution · 2025Article
- Meeting Report on the Symposium "Evolutionary Applications" at the 3rd Joint Congress on Evolutionary Biology.Evolutionary applications · 2025Article
- Engineering drive-selection balance for localized population suppression with neutral dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A Y chromosome-linked genome editor for efficient population suppression in the malaria vector Anopheles gambiae.Nature communications · 2025Article
- Population suppression by release of insects carrying a dominant sterile homing gene drive targeting doublesex in Drosophila.Nature communications · 2024Article
- Expanding the CRISPR base editing toolbox in Drosophila melanogaster.Communications biology · 2024Article
- Population suppression with dominant female-lethal alleles is boosted by homing gene drive.BMC biology · 2024Article
- Targeting mosquito X-chromosomes reveals complex transmission dynamics of sex ratio distorting gene drives.Nature communications · 2024Article
- The haplolethal gene wupA of Drosophila exhibits potential as a target for an X-poisoning gene drive.G3 (Bethesda, Md.) · 2024Article
- CRISPR-based gene drives generate super-Mendelian inheritance in the disease vector Culex quinquefasciatus.Nature communications · 2023Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In male heterogametic species the Y chromosome is transmitted solely from fathers to sons, and is selected for based only on its impacts on male fitness. This fact can be exploited to develop efficient pest control strategies that use Y-linked editors to disrupt the fitness of female descendants. With simple population genetic and dynamic models we show that Y-linked editors can be substantially more efficient than other self-limiting strategies and, while not as efficient as gene drive approaches, are expected to have less impact on non-target populations with which there is some gene flow. Efficiency can be further augmented by simultaneously releasing an autosomal X-shredder construct, in either the same or different males. Y-linked editors may be an attractive option to consider when efficient control of a species is desired in some locales but not others.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.