ArticleProceedings. Biological sciences2018
The evolution of constitutive and induced defences to infectious disease.
Article in Proceedings. Biological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Multilevel variation in pathogen susceptibility and grooming behavior in ant societies.Die Naturwissenschaften · 2026Article
- Coevolution of host resistance and pathogen exploitation in a propagule-mediated infection model.PLoS computational biology · 2026Article
- Review
- Altruistic disease signalling in ant colonies.Nature communications · 2025Article
- Multifaceted Defenses Against Parasitoid Wasps in Diptera.Annual review of genetics · 2025Review
- Links between Innate and Adaptive Immunity Can Favor Evolutionary Persistence of Immunopathology.Integrative and comparative biology · 2024Article
- Mapping the functional form of the trade-off between infection resistance and reproductive fitness under dysregulated immune signaling.PLoS pathogens · 2024Article
- The evolution of constitutively active humoral immune defenses in Drosophila populations under high parasite pressure.PLoS pathogens · 2024Article
- Pleiotropy promotes the evolution of inducible immune responses in a model of host-pathogen coevolution.PLoS computational biology · 2023Article
- Activation of immune defences against parasitoid wasps does not underlie the cost of infection.Frontiers in immunology · 2023Article
- Exploring the molecular basis of resistance toPeerJ · 2023Article
- Predation shifts coevolution toward higher host contact rate and parasite virulence.Proceedings. Biological sciences · 2022Article
- The Defense Response Involved in Sweetpotato Resistance to Root-Knot NematodeFrontiers in plant science · 2021Article
- Constitutive activation of cellular immunity underlies the evolution of resistance to infection ineLife · 2020Article
- Young but not defenceless: antifungal activity during embryonic development of a social insect.Royal Society open science · 2020Article
- The impact ofAoB PLANTS · 2020Article
- Stripe rust induced defence mechanisms in the leaves of contrasting barley genotypes (Hordeum vulgare L.) at the seedling stage.Protoplasma · 2020Article
- Tomato Domestication Attenuated Responsiveness to a Beneficial Soil Microbe for Plant Growth Promotion and Induction of Systemic Resistance to Foliar Pathogens.Frontiers in microbiology · 2020Article
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2 authors.
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Abstract
In response to infectious disease, hosts typically mount both constitutive and induced defences. Constitutive defence prevents infection in the first place, while induced defence typically shortens the infectious period. The two routes to defence, therefore, have very different implications not only to individuals but also to the epidemiology of the disease. Moreover, the costs of constitutive defences are likely to be paid even in the absence of disease, while induced defences are likely to incur the most substantial costs when they are used in response to infection. We examine theoretically the evolutionary implications of these fundamental differences. A key result is that high virulence in the parasite typically selects for higher induced defences even if they result in immunopathology leading to very high disease mortality. Disease impacts on fecundity are critical to the relative investment in constitutive and induced defence with important differences found when parasites castrate their hosts. The trade-off between constitutive and induced defence has been cited as a cause of the diversity in defence, but we show that the trade-off alone is unlikely to lead to diversity. Our models provide a framework to examine relative investment in different defence components both experimentally and in the field.
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