ArticleProceedings. Biological sciences2018
Proteomic evidence of dietary sources in ancient dental calculus.
Article in Proceedings. Biological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 155 citations in OpenAlex.
- The Oral Microbiome of King Richard III of England.American journal of biological anthropology · 2026Article
- Dental Calculus Formation Is Linked to Diet and Phylogeny in Mammals.Ecology and evolution · 2026Article
- Paleoproteomics of pottery food residues reveals plant cupin superfamily proteins preserved for thousands of years.iScience · 2026Article
- Paleo-proteomic analysis of Iron Age dental calculus provides direct evidence of Scythian reliance on ruminant dairy.PloS one · 2026Article
- Health and lifestyle in the Iron Age Italian community of Pontecagnano (Campania, Italy, 7th-6th century BCE).PloS one · 2026Article
- The Demodifier: A tool for screening modification-induced alternate peptide taxonomy in palaeoproteomics.PloS one · 2026Article
- Polygenic prediction of human complex traits using ancient DNA.Current opinion in genetics & development · 2025Review
- An extensive archaeological dental calculus dataset spanning 5000 years for ancient human oral microbiome research.Data in brief · 2025Article
- Reconstructing medieval diets through the integration of stable isotope and proteomic analyses from two European burial sites.Scientific reports · 2025Article
- The impact of dietary interventions on cardiometabolic health.Cardiovascular diabetology · 2025Review
- An unclean slate, discrepancies between food input and recovered protein signal from experimental foodcrusts.PloS one · 2025Article
- The impact of cooking and burial on proteins: a characterisation of experimental foodcrusts and ceramics.Royal Society open science · 2024Article
- Human brains preserve in diverse environments for at least 12 000 years.Proceedings. Biological sciences · 2024Article
- Human diet of premodern mainland Japan: a meta-analysis of carbon and nitrogen stable isotope ratios.Anthropological science : journal of the Anthropological Society of Nippon = Jinruigaku zasshi · 2024Article
- Article
- Extraction Protocol for Parallel Analysis of Proteins and DNA from Ancient Teeth and Dental Calculus.Journal of proteome research · 2023Article
- Curated cauldrons: Preserved proteins from early copper-alloy vessels illuminate feasting practices in the Caucasian steppe.iScience · 2023Article
- Beyond dirty teeth: Integrating dental calculus studies with osteoarchaeological parameters.Quaternary international : the journal of the International Union for Quaternary Research · 2023Article
- Paleoproteomic evidence reveals dairying supported prehistoric occupation of the highland Tibetan Plateau.Science advances · 2023Article
- Permafrost preservation reveals proteomic evidence for yak milk consumption in the 13Communications biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 11 institutions in 7 countries.
Funding
Abstract
Archaeological dental calculus has emerged as a rich source of ancient biomolecules, including proteins. Previous analyses of proteins extracted from ancient dental calculus revealed the presence of the dietary milk protein β-lactoglobulin, providing direct evidence of dairy consumption in the archaeological record. However, the potential for calculus to preserve other food-related proteins has not yet been systematically explored. Here we analyse shotgun metaproteomic data from 100 archaeological dental calculus samples ranging from the Iron Age to the post-medieval period (eighth century BC to nineteenth century AD) in England, as well as 14 dental calculus samples from contemporary dental patients and recently deceased individuals, to characterize the range and extent of dietary proteins preserved in dental calculus. In addition to milk proteins, we detect proteomic evidence of foodstuffs such as cereals and plant products, as well as the digestive enzyme salivary amylase. We discuss the importance of optimized protein extraction methods, data analysis approaches and authentication strategies in the identification of dietary proteins from archaeological dental calculus. This study demonstrates that proteomic approaches can robustly identify foodstuffs in the archaeological record that are typically under-represented due to their poor macroscopic preservation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.