ArticleMicrobiologyOpen2019
Antimicrobial efficacy of alternative compounds for use in oral care toward biofilms from caries-associated bacteria in vitro.
Article in MicrobiologyOpen, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Natural Agents for the Improvement of Gingival Health: Systematic Review and Meta-Analysis of Randomized Clinical Trials.Oral health & preventive dentistry · 2026Pooled it
- The Hygienic Significance of Microbiota and Probiotics for Human Wellbeing.Probiotics and antimicrobial proteins · 2025Review
- The antibiofilm effect and mechanism of silver nanowire-modified glass ionomer cement against multi-species oral biofilm.BMC oral health · 2025Article
- Cerium chloride pretreatment reduces initial biofilm attachment on hydroxyapatite: a scanning electron microscopy study.Frontiers in oral health · 2025Article
- Viable but non-cultivable state in oral microbiota: a critical review of an underexplored microbial survival strategy.Frontiers in cellular and infection microbiology · 2025Review
- Caries Etiology and Preventive Measures.European journal of dentistry · 2024Article
- VesiX cetylpyridinium chloride is rapidly bactericidal and reduces uropathogenicMicrobiology spectrum · 2024Article
- Optimal effective concentration combinations (OPECCs) for binary application of membrane-targeting antiseptics and TMPyP-mediated antimicrobial photodynamic therapy.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024Article
- Mouthwash Effects on the Oral Microbiome: Are They Good, Bad, or Balanced?International dental journal · 2023Review
- A graphene microelectrode array based microfluidic device forNanoscale advances · 2023Article
- Preprocedural mouthwashes for infection control in dentistry-an update.Clinical oral investigations · 2023Review
- Overview on Adjunct Ingredients Used in Hydroxyapatite-Based Oral Care Products.Biomimetics (Basel, Switzerland) · 2022Review
- Incorporation of Fluoride into Human Teeth after Immersion in Fluoride-Containing Solutions.Dentistry journal · 2022Article
- Effects of bioflavonoid-containing mouth rinses on optical properties of tooth-coloured dental restorative materials.Scientific reports · 2022Article
- Phenotypic Adaptation to Antiseptics and Effects on Biofilm Formation Capacity and Antibiotic Resistance in Clinical Isolates of Early Colonizers in Dental Plaque.Antibiotics (Basel, Switzerland) · 2022Article
- Study on the inhibitory effect of selective estrogen receptor modulators onHua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2022Article
- Transcriptomic Stress Response inMicroorganisms · 2022Article
- Membrane damage as mechanism of photodynamic inactivation using Methylene blue and TMPyP in Escherichia coli and Staphylococcus aureus.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2022Article
- Development of standard protocols for biofilm-biomaterial interface testing.JADA foundational science · 2022Review
- Cariogenic Biofilms: Development, Properties, and Biomimetic Preventive Agents.Dentistry journal · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For caries-active patients, antimicrobial measures may be useful in addition to mechanical biofilm removal. The aim of this study was to investigate the antimicrobial efficacy of alternative compounds for use in oral care from two main categories (i.e., preservatives and natural compounds) toward biofilms from caries-associated bacteria as compared to oral care gold-standards chlorhexidine digluconate (CHX), cetylpyridinium chloride (CPC), and zinc. Compounds were screened in initial Streptococcus mutans biofilms. Then, the most effective compounds were further investigated in mature S. mutans and polymicrobial biofilms comprising Actinomyces naeslundii, Actinomyces odontolyticus, and S. mutans. Here, distinct treatment periods and concentrations were evaluated. Biofilms were visualized by scanning electron microscopy and bacterial membrane damage was evaluated by means of flow cytometry and staining with SYBR Green and propidium iodide. Citrus extract was the only compound exhibiting similar antimicrobial efficacy in initial S. mutans biofilms (>5 log
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.