ArticleLasers in surgery and medicine2019
Upper airway reconstruction using long-range optical coherence tomography: Effects of airway curvature on airflow resistance.
Article in Lasers in surgery and medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Biomechanical analysis of upper airway airflow characteristics in children.Sleep & breathing = Schlaf & Atmung · 2026Article
- Decoding the mechanophysiology for inhaled onset of smallpox with model-based implications for mpox spread.Scientific reports · 2025Article
- Nasal microbiota dysbiosis and functional alterations in children with adenoid hypertrophy: potential biomarkers and post-surgical microbial recovery.Applied microbiology and biotechnology · 2025Article
- Comparative analysis of drug deposition patterns among three commercial nasal spray brands: A computational and experimental study.Journal of molecular liquids · 2025Article
- Insights into exercise-induced rhinitis based on nasal aerodynamics induced by airway morphology.Respiratory physiology & neurobiology · 2024Article
- Adults with Treacher Collins Syndrome Share Comparable 3D Upper Airway Dimensions with Nonsyndromic Individuals.International journal of dentistry · 2024Article
- Effects of 3D Airway Geometry on the Airflow of Adults with Cleft Lip and Palate and Obstructive Sleep Apnea: A Functional Imaging Study.Sleep science (Sao Paulo, Brazil) · 2023Article
- Computational fluid-structure interaction analysis of flapping uvula on aerodynamics and pharyngeal vibration in a pediatric airway.Scientific reports · 2023Article
- On a model-based approach to improve intranasal spray targeting for respiratory viral infections.Frontiers in drug delivery · 2023Article
- A computational analysis on the impact of multilevel laryngotracheal stenosis on airflow and drug particle dynamics in the upper airway.Experimental and computational multiphase flow · 2023Article
- On the design of particle filters inspired by animal noses.Journal of the Royal Society, Interface · 2022Article
- Effect of adenoid hypertrophy on the upper airway and craniomaxillofacial region.Translational pediatrics · 2021Article
- Orally Inhaled Drug Particle Transport in Computerized Models of Laryngotracheal Stenosis.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2021Article
- Computational characterization of inhaled droplet transport to the nasopharynx.Scientific reports · 2021Article
- Intraoperative use of optical coherence tomography to differentiate normal and diseased thyroid and parathyroid tissues from lymph node and fat.Lasers in medical science · 2021Article
- Numerical evaluation of spray position for improved nasal drug delivery.Scientific reports · 2020Article
- Geometric Validation of Continuous, Finely Sampled 3-D Reconstructions From aOCT and CT in Upper Airway Models.IEEE transactions on medical imaging · 2019Article
- Sensitivity of nasal airflow variables computed via computational fluid dynamics to the computed tomography segmentation threshold.PloS one · 2018Article
- Narrowed Posterior Nasal Airway Limits Efficacy of Anterior Septoplasty.Facial plastic surgery & aesthetic medicineArticle
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesAdenotonsillectomy (AT) is commonly used to treat upper airway obstruction in children, but selection of patients who will benefit most from AT is challenging. The need for diagnostic evaluation tools without sedation, radiation, or high costs has motivated the development of long-range optical coherence tomography (LR-OCT), providing real-time cross-sectional airway imaging during endoscopy. Since the endoscope channel location is not tracked in conventional LR-OCT, airway curvature must be estimated and may affect predicted airway resistance. The study objective was to assess effects of three realistic airway curvatures on predicted airway resistance using computational fluid dynamics (CFD) in LR-OCT reconstructions of the upper airways of pediatric patients, before and after AT.
methodsEight subjects (five males, three females, aged 4-9 years) were imaged using LR-OCT before and after AT during sedated endoscopy. Three-dimensional (3D) airway reconstructions included three airway curvatures. Steady-state, inspiratory airflow simulations were conducted under laminar conditions, along with turbulent simulations for one subject using the k-ω turbulence model. Airway resistance (pressure drop/flow) was compared using two-tailed Wilcoxon signed rank tests.
resultsRegardless of the airway curvatures, CFD findings corroborate a surgical end-goal with computed post-operative airway resistance significantly less than pre-operative (P < 0.01). The individual resistances did not vary significantly for different airway curvatures (P > 0.25). Resistances computed using turbulent simulations differed from laminar results by less than ∼5%.
conclusionsThe results suggest that reconstruction of the upper airways from LR-OCT imaging data may not need to account for airway curvature to be predictive of surgical effects on airway resistance. Lasers Surg. Med. 51:150-160, 2019. © 2018 Wiley Periodicals, Inc.
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