ArticleMicrobiologyOpen2019
A simplified curcumin targets the membrane of Bacillus subtilis.
Article in MicrobiologyOpen, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Probiotic-Plant Bioactive Synergy in Gut Health: Mechanisms, Antimicrobial Activity, and Translational Challenges.Nutrients · 2026Review
- Antibacterial and antibiofilm activities of curcumin-mediated green-synthesised silver nanoparticles against Methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa.BMC biotechnology · 2026Article
- Curcumin and Curcuminoids: Biological Activities and Clinical Studies.Current medicinal chemistry · 2026Review
- Synergistic Interactions Between Natural Phenolic Compounds and Antibiotics Against Multidrug-ResistantMicroorganisms · 2025Article
- Effects of Curcumin on Biofilm Production and Associated Gene in Multidrug-ResistantInternational journal of molecular and cellular medicine · 2025Article
- Curcumin, an active component of turmeric: biological activities, nutritional aspects, immunological, bioavailability, and human health benefits - a comprehensive review.Frontiers in immunology · 2025Review
- EnvC Homolog Encoded byMicroorganisms · 2024Article
- Antibiofilm, Antimicrobial, Anti-Quorum Sensing, and Antioxidant Activities of Saudi Sidr Honey: In Vitro and Molecular Docking Studies.Pharmaceutics · 2023Article
- Curcumin assisted green synthesis of silver and zinc oxide nanostructures and their antibacterial activity against some clinical pathogenic multi-drug resistant bacteria.RSC advances · 2022Article
- Recent Research on Hybrid Hydrogels for Infection Treatment and Bone Repair.Gels (Basel, Switzerland) · 2022Review
- Evaluation of calcium hydroxide, calcium hypochlorite, peracetic acid, and potassium bicarbonate as citrus fruit sanitizers.Journal of food science and technology · 2022Article
- The Natural Product Curcumin as an Antibacterial Agent: Current Achievements and Problems.Antioxidants (Basel, Switzerland) · 2022Review
- Antibacterial Activity of Isobavachalcone (IBC) Is Associated with Membrane Disruption.Membranes · 2022Article
- Endophytes of Brazilian Medicinal Plants With Activity Against Phytopathogens.Frontiers in microbiology · 2021Article
- Investigating the Modes of Action of the Antimicrobial Chalcones BC1 and T9A.Molecules (Basel, Switzerland) · 2020Article
- Curcumin loaded zinc oxide nanoparticles for activity-enhanced antibacterial and anticancer applications.RSC advances · 2020Article
- mCherry fusions enable the subcellular localization of periplasmic and cytoplasmic proteins in Xanthomonas sp.PloS one · 2020Article
- Repurposing of Drugs for Antibacterial Activities on Selected ESKAPE BacteriaInternational journal of microbiology · 2020Article
- A simplified curcumin targets the membrane of Bacillus subtilis.MicrobiologyOpen · 2019Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Curcumin is the main constituent of turmeric, a seasoning popularized around the world with Indian cuisine. Among the benefits attributed to curcumin are anti-inflammatory, antimicrobial, antitumoral, and chemopreventive effects. Besides, curcumin inhibits the growth of the gram-positive bacterium Bacillus subtilis. The anti-B. subtilis action happens by interference with the division protein FtsZ, an ancestral tubulin widespread in Bacteria. FtsZ forms protofilaments in a GTP-dependent manner, with the concomitant recruitment of essential factors to operate cell division. By stimulating the GTPase activity of FtsZ, curcumin destabilizes its function. Recently, curcumin was shown to promote membrane permeabilization in B. subtilis. Here, we used molecular simplification to dissect the functionalities of curcumin. A simplified form, in which a monocarbonyl group substituted the β-diketone moiety, showed antibacterial action against gram-positive and gram-negative bacteria of clinical interest. The simplified curcumin also disrupted the divisional septum of B. subtilis; however, subsequent biochemical analysis did not support a direct action on FtsZ. Our results suggest that the simplified curcumin exerted its function mainly through membrane permeabilization, with disruption of the membrane potential necessary for FtsZ intra-cellular localization. Finally, we show here experimental evidence for the requirement of the β-diketone group of curcumin for its interaction with FtsZ.
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