Evidence map›Paper›PMID 30051553›Full record

ArticleHead & neck2018

Pretreatment metabolic tumor volume as a prognostic factor in HPV-associated oropharyngeal cancer in the context of AJCC 8th edition staging.

John M Floberg, Todd A DeWees, Re-I Chin, Adam A Garsa, Farrokh Dehdashti, Brian Nussenbaum, Peter J Oppelt, Douglas R Adkins, Hiram A Gay, Wade L Thorstad

Abstract read
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In one paragraph

Article in Head & neck, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. CT and FDG-PET radiologic biomarkers in p16+ oropharyngeal squamous cell carcinoma patients treated with definitive chemoradiotherapy.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2021
    Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

John M FlobergWashington University School of Medicine, Department of Radiation Oncology, St Louis, MO.ORCID 0000-0002-7635-7554
Todd A DeWeesMayo Clinic, Department of Biomedical Statistics and Informatics Scottsdale, AZ.
Re-I ChinSt Louis University School of Medicine, St Louis, MO.
Adam A GarsaKeck School of Medicine of University of Southern California, Department of Radiation Oncology, Los Angeles, CA.
Farrokh DehdashtiWashington University School of Medicine, Mallinckrodt Institute of Radiology Division of Nuclear Medicine, St Louis, MO.
Brian NussenbaumAmerican Board of Otolaryngology, Houston, TX.
Peter J OppeltWashington University School of Medicine, Department of Internal Medicine, Division of Oncology, St Louis, MO.
Douglas R AdkinsWashington University School of Medicine, Department of Internal Medicine, Division of Oncology, St Louis, MO.
Hiram A GayWashington University School of Medicine, Department of Radiation Oncology, St Louis, MO.
Wade L ThorstadWashington University School of Medicine, Department of Radiation Oncology, St Louis, MO.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study evaluates the prognostic significance of

methodsWe performed a retrospective study of HPV-associated OPSCCs treated with postoperative or definitive radiation. The prognostic significance of pretreatment MTV for freedom from recurrence (FFR), freedom from distant metastasis (FFDM), and overall survival (OS) was determined using Kaplan-Meier analysis. Multivariate analysis (MVA) was performed using Cox regression.

resultsIn this 153-patient cohort, stratifying by the optimum MTV (24 cm

conclusionMetabolic tumor volume (MTV) is a significant prognostic factor in HPV-associated OPSCCs, independent of AJCC 8th edition stage.

Indexed as

Tumor BurdenAdultAgedAged, 80 and overCarcinoma, Squamous CellFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedNeoplasm MetastasisNeoplasm Recurrence, LocalOropharyngeal NeoplasmsPapillomavirus InfectionsPositron Emission Tomography Computed TomographyPrognosisFluorodeoxyglucose F18Radiopharmaceuticalshuman papillomavirus (HPV)metabolic tumor volumeoropharyngeal cancerpositron emission tomographyprognostic markers

Identifiers

PMID30051553

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.