ArticleActa anaesthesiologica Scandinavica2019
Volatile anaesthetics and postoperative delirium in older surgical patients-A secondary analysis of prospective cohort studies.
Article in Acta anaesthesiologica Scandinavica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed.
- Effect of desflurane versus propofol on perioperative neurocognitive disorders in older adults undergoing major urological surgery: a randomized trial.BMC geriatrics · 2026Trial
- Impact of desflurane versus isoflurane on early cognitive function of the elderly undergoing lumbar surgery: a randomized clinical trial.BMC anesthesiology · 2025Trial
- Increasing interleukin-17 induced by β-Amyloid deposition is involved in early cognitive decline after sevoflurane anesthesia.Experimental brain research · 2025Article
- [Risk of postoperative delirium in older adults under balanced general anesthesia].Revista medica del Instituto Mexicano del Seguro Social · 2024Article
- Effects of volatile anesthetics on circadian rhythm in mice: a comparative study of sevoflurane, desflurane, and isoflurane.Journal of anesthesia · 2024Article
- Postoperative delirium: identifying the patient at risk and altering the course: A narrative review.European journal of anaesthesiology and intensive care · 2023Review
- Implementation of strategies to prevent and treat postoperative delirium in the post-anesthesia caring unit : A German survey of current practice.Journal of clinical monitoring and computing · 2021Article
- ATPase Inhibitory Factor 1 Is Critical for Regulating Sevoflurane-Induced Microglial Inflammatory Responses and Caspase-3 Activation.Frontiers in cellular neuroscience · 2021Article
- Management of Ambulatory Anesthesia in Older Adults.Drugs & aging · 2020Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundVolatile Anaesthetics (VAs) may be associated with postoperative delirium (POD). However, to date, the effects of VAs on POD are not completely understood. The objective of this study was to investigate the incidence of POD in different VA groups.
methodsA secondary analysis was conducted using a database created from prospective cohort studies in patients who underwent elective major noncardiac surgery. Patients who received general anaesthesia with desflurane, isoflurane, or sevoflurane were included in the study. POD occurring on either of the first two postoperative days was measured using the Confusion Assessment Method.
resultsFive hundred and thirty-two patients were included in this study, with a mean age of 73.5 ± 6.0 years (range, 65-96 years). The overall incidence of POD on either postoperative day 1 or 2 was 41%. A higher incidence of POD was noted in the desflurane group compared with the isoflurane group (Odds Ratio = 3.35, 95% CI = 1.54-7.28). The incidence of POD between the sevoflurane and isoflurane or desflurane group was not statistically significant.
conclusionEach VA may have different effects on postoperative cognition. Further studies using a prospective randomized approach will be necessary to discern whether anaesthetic type or management affects the occurrence of postoperative delirium.
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