Evidence map›Paper›PMID 30051393›Full record

ReviewAdvances in experimental medicine and biology

Sex-Specific Characteristics of the Microcirculation.

Virginia H Huxley, Scott S Kemp

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in experimental medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Relevance of Microvascular Flow Assessments in Critically Ill Neonates and Children: A Systematic Review.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2020
    Pooled it
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  16. Drug design, development and therapy · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Virginia H HuxleyCenter for Gender Physiology, Department of Medical Pharmacology and Physiology, School of Medicine, University of Missouri, Columbia, MO, USA. huxleyv@health.missouri.edu.
Scott S KempCenter for Gender Physiology, Department of Medical Pharmacology and Physiology, School of Medicine, University of Missouri, Columbia, MO, USA.

Funding

Insulin as a Regulator of Microvascular ExchangeR01DK095501 · NIDDK · UNIVERSITY OF MISSOURI-COLUMBIA · PI HUXLEY, VIRGINIA H · 2013 to 2016
$1.5M
NIDDK NIH HHS R01 DK095501
6 · The paper itself

Abstract

The requirements of metabolizing tissue are both continuous and variable; accordingly, the microvasculature serving that tissue must be similarly dynamic. Just as it is recognized that males and females of the same species have differing metabolic requirements, is it not likely that the microvasculature serving these tissues will differ by sex? This section focusing on the constituents of the microcirculation identifies what is known presently about the role sex plays in matching metabolic demand with microvascular function and areas requiring additional study. Many of the identified sex differences are subtle and easily ignored. In the aggregate, though, they can profoundly alter phenotype, especially under stressful conditions including pregnancy, exercise, and disease states ranging from diabetes to heart failure. Although the features presently identified to "have sex" range from differences in growth, morphology, protein expression, and intracellular signaling, males and females alike achieve homeostasis, likely by different means. Studies of microvascular sexual dimorphism are also identifying age as an independent but interacting factor requiring additional attention. Overall, attempting to ignore either sex and/or age is inappropriate and will prevent the design and implementation of appropriate interventions to present, ameliorate, or correct microvascular dysfunction.

Indexed as

Health Status DisparitiesMicrocirculationAnimalsCardiovascular DiseasesFemaleHormonesHumansMaleMenstrual CycleMicrovesselsModels, CardiovascularPhenotypeRisk FactorsSex CharacteristicsSex FactorsHormonesAquaporinArteriolesBarrier functionBlood flow regulationCapillariesCoronary microvascular dysfunctionEndotheliumFibrinolysisFluid homeostasisGlycocalyxHydrostatic pressureHypertensionLymphaticsMicrocirculationMicrovascular networkMyogenic responseOrthostatic intolerancePericytePeripheral resistancePregnancyRarefactionSepsisSex differenceSexual dimorphismSyndecan-1Vascular homeostasisVenules

Identifiers

PMID30051393
PMCPMC6209095

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.