ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2018
Clonal diversity of Ureaplasma species and its relationship with oligozoospermia and semen quality in Chinese infertile males.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Characterization of cervical fluid Ureaplasma species in pregnant women with spontaneous preterm delivery.Scientific reports · 2025Article
- Lifestyle and Environmental Factors Affecting Male Fertility, Individual Predisposition, Prevention, and Intervention.International journal of molecular sciences · 2025Review
- Characterization of Amniotic Fluid Ureaplasma Species from Pregnancies Complicated by Preterm Prelabor Rupture of Membranes.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Microbiology and immune mechanisms associated with male infertility.Frontiers in immunology · 2023Review
- Exploring the Mechanism of Zhibai Dihuang Decoction in the Treatment of Ureaplasma Urealyticum-Induced Orchitis Based on Integrated Pharmacology.Frontiers in pharmacology · 2021Article
- Antimicrobial resistance, genetic characterization, and molecular epidemiology of Ureaplasma species in males with infertility.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Article
- Association of Semen Bacteriological Profile with Infertility:- A Cross-Sectional Study in a Tertiary Care Center.Journal of human reproductive sciencesArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Whether Ureaplasma spp. are a causative agent of male infertility remains controversial. Previous studies concerning Ureaplasma spp. and male infertility have been confined to the species level of Ureaplasma. Currently, an expanded multilocus sequence typing (eMLST) scheme has been established with high discriminatory power. The aim of this study was to use eMLST to explore the distribution of Ureaplasma spp. and to analyze its role in oligozoospermia and semen quality. A total of 480 semen samples were obtained from Chinese infertile males. The associations between Ureaplasma spp. with oligozoospermia and semen characteristics were further evaluated. Phylogenetic analysis revealed that 102 Ureaplasma spp. could be separated into two clusters and seven sub-groups. Within cluster I (U. parvum), eST16 and eST41 were the most frequent clones. For cluster II (U. urealyticum), eST82 and eST147 were the most prevalent clones. Sub-groups A and C belonging to cluster I and sub-group 1 belonging to cluster II showed an association with oligozoospermia, in contrast with the Ureaplasma spp. negative group (P < 0.05). Compared with the negative group, semen motility decreased in sub-group 2, especially for non-progressive motility (P < 0.05). These results indicated that sub-groups A and C belonging to cluster I (U. parvum) and sub-group 1 belonging to cluster II (U. urealyticum) were shown to be associated with oligozoospermia. Sub-group 2 belonging to cluster II may have the ability to impair semen motility, especially for non-progressive motility.
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