Evidence map›Paper›PMID 30051275›Full record

ArticleDer Pathologe2019

[Primary meningioma of the optical nerve sheet in infancy as initial presentation of neurofibromatosis type 2].

S Theurer, E Biewald, K Kuchelmeister, P Temming, A Kuechler, F Oeffner, N Bornfeld, S Sirin, K W Schmid, K Metz

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Der Pathologe, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. [Diagnosis at first sight].Der Radiologe · 2021
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

S TheurerInstitut für Pathologie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstraße 55, 45147, Essen, Deutschland. sarah.theurer@uk-essen.de.
E BiewaldKlinik für Augenheilkunde, Universitätsklinikum Essen, Universität Duisburg-Essen, Essen, Deutschland.
K KuchelmeisterInstitut für Neuropathologie, Universitätsklinikum Bonn, Universität Bonn, Bonn, Deutschland.
P TemmingKlinik für Kinderheilkunde III, Universitätsklinikum Essen, Universität Duisburg-Essen, Essen, Deutschland.
A KuechlerInstitut für Humangenetik, Universitätsklinikum Essen, Universität Duisburg-Essen, Essen, Deutschland.
F Oeffnergenetikum Neu-Ulm, Wegenerstraße 15, 89231, Neu-Ulm, Deutschland.
N BornfeldKlinik für Augenheilkunde, Universitätsklinikum Essen, Universität Duisburg-Essen, Essen, Deutschland.
S SirinInstitut für diagnostische und interventionelle Radiologie und Neuroradiologie, Universitätsklinikum Essen, Universität Duisburg-Essen, Essen, Deutschland.
K W SchmidInstitut für Pathologie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstraße 55, 45147, Essen, Deutschland.
K MetzInstitut für Pathologie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstraße 55, 45147, Essen, Deutschland.
University of Duisburg-Essen · DEEssen University Hospital · DEGenetikum · DEUniversity Hospital Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intraorbital meningiomas are rare tumors, making up less than 4% of all intraorbital tumors. Intraorbital meningiomas of childhood are curiosities with only few documented cases. We present the case of an 8‑month-old male infant, presenting with strabismus and nystagmus. Magnetic resonance imaging showed a long segment thickening of the optical nerve and an intraocular tumor. The tumor was suspicious for retinal dysplasia and enucleation of the eye was performed to exclude malignancy. Histological examination revealed a meningothelial meningioma (WHO grade I), extending along the optical nerve and into the eye accompanied by retinal dysplasia and epiretinal membranes. Meningiomas of childhood, retinal dysplasia, and epiretinal membranes are regularly associated with neurofibromatosis type 2. Subsequent genetic analysis led to the final diagnosis. This case documents a very unusual early beginning of a neurofibromatosis type 2.

Indexed as

Meningeal NeoplasmsMeningiomaNeurofibromatosis 2HumansInfantMagnetic Resonance ImagingMaleDifferential diagnosis retinoblastomaIntraorbital tumorMeningioma of optical nerveNeurofibromatosis type 2Ocular malformationOptical nerve sheet tumorOrbital tumors of childhood

Identifiers

PMID30051275
OpenAlexW2884432406

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.