Evidence map›Paper›PMID 30051222›Full record

Trial reportInternational journal of clinical pharmacy2018

Pharmacist's interventions improve time in therapeutic range of elderly rural patients on warfarin therapy: a randomized trial.

Slaven Falamić, Marko Lucijanić, Maja Ortner Hadžiabdić, Srećko Marušić, Vesna Bačić Vrca

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in International journal of clinical pharmacy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Slaven FalamićCommunity Pharmacy Branka Marušić, Trg Ante Starčevića 24, 31540, Donji Miholjac, Croatia. sfalamic1983@gmail.com.ORCID http://orcid.org/0000-0001-7229-3840
Marko LucijanićHematology Department, University Hospital Dubrava, Avenija Gojka Suska 6, 10000, Zagreb, Croatia.
Maja Ortner HadžiabdićCentre for Applied Pharmacy, University of Zagreb, Faculty of Pharmacy and Biochemistry, Ante Kovačića 1, 10000, Zagreb, Croatia.
Srećko MarušićDepartment of Clinical pharmacology, University Hospital Dubrava, Avenija Gojka Suska 6, 10000, Zagreb, Croatia.
Vesna Bačić VrcaDepartment of Clinical pharmacy, University Hospital Dubrava, Avenija Gojka Suska 6, 10000, Zagreb, Croatia.
University Hospital Dubrava · HRUniversity of Zagreb · HRZdravstveni centar · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Community pharmacists can play an important role in optimizing warfarin treatment, which is very important in vulnerable patient groups such as the elderly patients in rural areas. Objective To evaluate the impact of a community pharmacist's interventions on the quality of anticoagulation in elderly rural patients receiving warfarin. Setting A community pharmacy in Donji Miholjac in Croatia's province of Slavonia. Method We conducted a prospective randomized trial. Eligible patients were recruited at the pharmacy and randomized into two groups. All participants were followed up monthly for a period of 6 months. Repeated education and a follow up plan were provided to the participants in the intervention group, and their general practitioners were contacted to correct the warfarin dose or to avoid drug interactions. Main outcome measure Time in therapeutic range (TTR) calculated by the Rosendaal method. Results A total of 140 patients were randomized and 131 patients finished the study, 65 patients in the intervention group. Median age was 73 years. At the end of the follow-up period, the median TTR was significantly higher in the intervention group (93 vs. 31.2% for intervention and control, respectively; P < 0.001). The proportion of patients with TTR ≥ 65% was also significantly higher in the intervention group (86.2 vs. 7.6% for intervention and control, respectively; P < 0.001). Factors independently associated with TTR ≥ 65% were intervention (P < 0.001), less frequent dose change (P = 0.005), better adherence (P < 0.001) and less variable vitamin K intake (P = 0.010).

Indexed as

Professional RoleRural PopulationAgedAged, 80 and overAnticoagulantsCommunity Pharmacy ServicesCroatiaDouble-Blind MethodEarly Medical InterventionFemaleFollow-Up StudiesHumansInternational Normalized RatioMalePharmacistsProspective StudiesAnticoagulantsWarfarinAnticoagulationCroatiaElderlyPharmacist interventionRural populationWarfarin

Identifiers

PMID30051222
OpenAlexW2884227102

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.