Evidence map›Paper›PMID 30051186›Full record

Observational studyClinical research in cardiology : official journal of the German Cardiac Society2019

Iron deficiency in patients with heart failure with preserved ejection fraction and its association with reduced exercise capacity, muscle strength and quality of life.

Tarek Bekfani, Pierpaolo Pellicori, Daniel Morris, Nicole Ebner, Miroslava Valentova, Anja Sandek, Wolfram Doehner, John G Cleland, Mitja Lainscak, P Christian Schulze and 2 more

2 registry-linked trialsOpen access · greenAbstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Clinical research in cardiology : official journal of the German Cardiac Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 59 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 2 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03845309 nacompletednot on this map

The Effect of Using Nutrition Education as an Intervention Measure on Elevating the Nutritional Status, Quality of Life, and Self-Care Behavior of Patients With Chronic Heart Failure

TypeinterventionalSponsorNational Taiwan University HospitalRan2019 to 2020Enrolled95ConditionsChronic Heart Failure, NutritionArmsSelf-Care Behavior
NCT07053475 phase4terminatednot on this mapstarted 2025, after this paper: background citation

IRONICA: IRON Repletion in Congestive Heart Failure - A Randomized Controlled Trial Comparing Oral Versus IV Approaches

TypeinterventionalSponsorSyed Hamza MufarrihRan2025 to 2026Enrolled42ConditionsHeart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF), Heart Failure With Preserved Ejection Fraction (HFPEF), Iron DeficiencyArmsFerric Carboxymaltose, Ferrous Sulfate
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 101 citations in OpenAlex.

  1. Efficacy and safety of intravenous iron repletion in patients with heart failure: a systematic review and meta-analysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2023
    Pooled it
  2. Pooled it
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  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
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  11. ANMCO position paper: diagnosis and treatment of heart failure with preserved systolic function.European heart journal supplements : journal of the European Society of Cardiology · 2025
    Article
  12. Article
  13. Article
  14. Iron Metabolism in Cardiovascular Disease.Advances in experimental medicine and biology · 2025
    Review
  15. Review
  16. Article
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  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Tarek BekfaniDepartment of Cardiology, Campus Virchow-Klinikum, Charité Medical School, Berlin, Germany. tarek.bekfani@med.uni-jena.de.ORCID http://orcid.org/0000-0003-0844-934X
Pierpaolo PellicoriDepartment of Cardiology, University of Hull, Hull, UK.
Daniel MorrisDepartment of Cardiology, Campus Virchow-Klinikum, Charité Medical School, Berlin, Germany.
Nicole EbnerDepartment of Cardiology and Pneumology, University of Göttingen Medical Center, Göttingen, Germany.
Miroslava ValentovaDepartment of Cardiology and Pneumology, University of Göttingen Medical Center, Göttingen, Germany.
Anja SandekDepartment of Cardiology and Pneumology, University of Göttingen Medical Center, Göttingen, Germany.
Wolfram DoehnerDepartment of Cardiology, Campus Virchow-Klinikum, Charité Medical School, Berlin, Germany.
John G ClelandDepartment of Cardiology, University of Hull, Hull, UK.
Mitja LainscakDepartment of Cardiology, Golnik University, Golnik, Slovenia.
P Christian SchulzeDivision of Cardiology, Angiology, Pneumology and Intensive Medical Care, Department of Internal Medicine I, University Hospital Jena, Friedrich-Schiller-University, Jena, Germany.
Stefan D AnkerDivision of Cardiology and Metabolism-Heart Failure, Cachexia and Sarcopenia, Department of Cardiology, Campus Virchow-Klinikum, Charité Medical School, Berlin, Germany.
Stephan von HaehlingDepartment of Cardiology, Campus Virchow-Klinikum, Charité Medical School, Berlin, Germany.
MSB Medical School Berlin · DEUniversity of Göttingen · DEUniversity of Hull · GBFriedrich Schiller University Jena · DEUniversity Clinic of Pulmonary and Allergic Diseases Golnik · SI

Funding

the European Commission's 7th Framework program (FP7/2007-2013) 241558
6 · The paper itself

Abstract

backgroundThe prevalence of iron deficiency (ID) in outpatients with heart failure with preserved ejection fraction (HFpEF) and its relation to exercise capacity and quality of life (QoL) is unknown.

methods190 symptomatic outpatients with HFpEF (LVEF 58 ± 7%; age 71 ± 9 years; NYHA 2.4 ± 0.5; BMI 31 ± 6 kg/m

resultsOverall, 111 patients (58.4%) showed ID with 89 having low ferritin-ID (46.84%). 78 (41.1%) patients had isolated ID without anemia and 54 patients showed anemia (28.4%). ID was more prevalent in patients with more severe diastolic dysfunction: E/e' ≤ 8: 44.8% vs. E/e': 9-14: 53.2% vs. E/e' ≥ 15: 86.5% (p = 0.0004). Patients with ID performed worse during the 6MWT (420 ± 137 vs. 344 ± 124 m; p = 0.008) and had worse exercise time in CPX (645 ± 168 vs. 538 ± 178 s, p = 0.03). Patients with low ferritin-ID had lower QoL compared to those without ID (p = 0.03).

conclusionID is a frequent co-morbidity in HFpEF and is associated with reduced exercise capacity and QoL. Its prevalence increases with increasing severity of diastolic dysfunction.

Indexed as

Quality of LifeAgedAnemia, Iron-DeficiencyComorbidityEchocardiographyEnglandExercise ToleranceFemaleGermanyHeart FailureHumansIncidenceMaleMuscle StrengthPrevalenceProspective StudiesExercise capacityHeart failure with preserved ejection fractionIron deficiencyQuality of life

Identifiers

PMID30051186
OpenAlexW2884081916

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.