Evidence map›Paper›PMID 30050947›Full record

Trial reportBioMed research international2018

Comparative Histological and Histomorphometric Results of Six Biomaterials Used in Two-Stage Maxillary Sinus Augmentation Model after 6-Month Healing.

Gerardo La Monaca, Giovanna Iezzi, Maria Paola Cristalli, Nicola Pranno, Gian Luca Sfasciotti, Iole Vozza

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03496688 (Comparative Histological and Histomorphometric Results of Six Biomaterials Used in Two-stage Maxillary Sinus Augmentation Model After 6-month-healing), which is not on this map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03496688 nacompletednot on this map

Comparative Histological and Histomorphometric Results of Six Biomaterials Used in Two-stage Maxillary Sinus Augmentation Model After 6-month-healing

TypeinterventionalSponsorUniversity of Roma La SapienzaRan2015 to 2017Enrolled6ConditionsAtrophy, Jaw, Edentulous, Partially, Sinus Floor Augmentation, Bone SubstitutesArmsSinus floor augmentation
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Gerardo La MonacaDepartment of Sense Organs, Sapienza University of Rome, Rome, Italy.ORCID 0000-0001-6537-7050
Giovanna IezziDepartment of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Chieti Scalo, Italy.
Maria Paola CristalliDepartment of Biotechnologies and Medical Surgical Sciences, Sapienza University of Rome, Rome, Italy.ORCID 0000-0001-7583-7030
Nicola PrannoDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.
Gian Luca SfasciottiDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.
Iole VozzaDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.ORCID 0000-0001-8545-9889
Sapienza University of Rome · ITUniversity of Chieti-Pescara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the performances of six different bone substitute materials used as graft in maxillary sinus augmentation by means of histological and histomorphometric analysis of bone biopsies retrieved from human subjects after a 6-month healing period. MATERIALS AND

methodsSix consecutive patients (3 males, 3 females, aged 50-72 years), healthy, nonsmokers, and with good oral hygiene, presenting edentulous posterior maxilla with a residual bone crest measuring ≤ 4 mm in vertical height and 3 to 5 mm in horizontal thickness at radiographic examination, were selected to receive sinus augmentation and delayed implant placement. Under randomized conditions, sinus augmentation procedures were carried out using mineralized solvent-dehydrated bone allograft (MCBA), freeze-dried mineralized bone allograft (FDBA), anorganic bovine bone (ABB), equine-derived bone (EB), synthetic micro-macroporous biphasic calcium-phosphate block consisting of 70% beta-tricalcium phosphate and 30% hydroxyapatite (HA-

resultsThere were no postoperative complications or implant failures. The histological examination showed that all biomaterials were in close contact with newly formed bone, surrounding the graft granules with a bridge-like network. No signs of acute inflammation were observed. The histomorphometry revealed 20.1% newly formed bone for MCBA, 32.1% for FDBA, 16.1% for ABB, 22.8% for EB, 20.3% for HA-

conclusionsWithin the limitations of the present investigation, all the six tested biomaterials showed good biocompatibility and osteoconductive properties when used in sinus augmentation procedures, although the FDBA seemed to have a better histomorphometric result in terms of newly formed bone and residual graft material. This trial is registered with ClinicalTrials.gov Identifier (Registration Number): NCT03496688.

Indexed as

Biocompatible MaterialsBone TransplantationMaxillary SinusSinus Floor AugmentationAgedAnimalsBone SubstitutesCattleDental Implantation, EndosseousFemaleHorsesHumansLactationMaleMaxillaMiddle AgedBiocompatible MaterialsBone Substitutes

Identifiers

PMID30050947
PMCPMC6040296
OpenAlexW2809843842

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.