ReviewQuantitative imaging in medicine and surgery2018
The role of radioprotective spacers in clinical practice: a review.
Review in Quantitative imaging in medicine and surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Pooled it
- Association of the Placement of a Perirectal Hydrogel Spacer With the Clinical Outcomes of Men Receiving Radiotherapy for Prostate Cancer: A Systematic Review and Meta-analysis.JAMA network open · 2020Pooled it
- Hyaluronic acid spacer in prostate cancer radiotherapy: dosimetric effects, spacer stability and long-term toxicity and PRO in a phase II study.Radiation oncology (London, England) · 2023Trial
- Factors Associated With Rectal Spacer Use in Prostate Cancer Patients Receiving Radiation Therapy.Cancer medicine · 2026Article
- Real-World Medical Device Reports of SpaceOAR Hydrogel Spacer: Analysis of the Food and Drug Administration Manufacturer and User Facility Device Experience (MAUDE) Database.Advances in radiation oncology · 2025Article
- Utilization of a stabilized hyaluronic acid spacer in SBRT for retroperitoneal cancers: A case series and dosimetric analysis.Clinical and translational radiation oncology · 2025Article
- Relationship Between Radiation Therapy and Fecal Incontinence in Patients Treated for Localized Prostate Cancer: Results of the French ICONES Study.The Prostate · 2025Article
- Protecting organs-at-risk in cancer therapies through temporary organ displacement: a comprehensive review.Oncology reviews · 2025Review
- Chest Wall Reconstruction in Ewing Sarcoma Using a Radioprotective Spacer.Surgical case reports · 2025Article
- Hydronephrosis Caused by Polyglycolic Acid Spacer Placement Prior to Carbon Ion Radiotherapy for Local Recurrence of Rectal Cancer: Case Report.Surgical case reports · 2025Article
- Radioprotection Performance Evaluation of 3D-Printed and Conventional Heat-Cured Dental Resins for Radiotherapy Prostheses.Journal of functional biomaterials · 2024Article
- The Use of Hydrogel-Based Materials for Radioprotection.Gels (Basel, Switzerland) · 2023Review
- Laparoscopic spacer placement for bulky lymph node metastasis of cervical cancer: A case report.Gynecologic oncology reports · 2022Article
- Evaluation of radiodensity and dimensional stability of polymeric materials used for oral stents during external beam radiotherapy of head and neck carcinomas.Clinical and translational radiation oncology · 2022Article
- Review
- Gel spacer to protect carotid artery and reconstructed jejunum in image-guided interstitial brachytherapy for recurrent hypopharyngeal cancer: a technical report.Journal of contemporary brachytherapy · 2021Article
- Benefits of contrast-enhanced ultrasonography for interventional procedures.Ultrasonography (Seoul, Korea) · 2021Article
- Radiation Chemical Investigation of Antioxidant Activity of Biologically Important Compounds from Plant Materials.ACS omega · 2020Article
- An Overview of the Cellular Mechanisms of Flavonoids Radioprotective Effects.Advanced pharmaceutical bulletin · 2020Review
- SpaceOAR to improve dosimetric outcomes for monotherapy high-dose-rate prostate implantation in a patient with ulcerative colitis.Journal of contemporary brachytherapy · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The delivery of high dose radiotherapy to tumors is often limited by the proximity of the surrounding radiosensitive normal tissues, even using modern techniques such as intensity modulated radiation therapy (IMRT). Previous studies have reported that placement of a spacer can effectively displace normal tissues. So that they are some distance away from the lesion, thus allowing for the safe delivery of high-dose radiation. The application of radioprotective spacers was first reported 30 years ago regarding radiotherapy of tongue and abdominal cancers; more recently, they are increasingly being used in prostate cancer. This review focuses on the published data concerning the features of different types of spacers and their application in various tumor sites. Placement-related complications and the cost-effectiveness of the spacers are also discussed. With the increasing use of high-precision radiotherapy in clinical practice, especially the paradigm-changing stereotactic body radiotherapy (SBRT), more robust studies are warranted to further establish the role of radioprotective spacers through materials development and novel placement techniques.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.