Evidence map›Paper›PMID 30050725›Full record

ArticleTranslational vision science & technology2018

Safety and Feasibility of a Novel Sparse Optical Coherence Tomography Device for Patient-Delivered Retina Home Monitoring.

Peter Maloca, Pascal W Hasler, Daniel Barthelmes, Patrik Arnold, Mooser Matthias, Hendrik P N Scholl, Heinrich Gerding, Justus Garweg, Tjebo Heeren, Konstantinos Balaskas and 4 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational vision science & technology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05223569 (Home Monitoring of Diabetic Macular Edema), which is not on this map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05223569 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Home Monitoring of Diabetic Macular Edema

TypeinterventionalSponsorZhongshan Ophthalmic Center, Sun Yat-sen UniversityRan2022 to 2024Enrolled120ConditionsMacular Edema Due to Diabetes MellitusArmsHome OCT monitoring model, Hospital-based monitoring with a staff-administrated OCT
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.

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  10. Intravitreal faricimab for neovascular age-related macular degeneration previously treated with traditional anti-VEGF compounds: a real-world prospective study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024
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  20. Applications and Current Medico-Legal Challenges of Telemedicine in Ophthalmology.International journal of environmental research and public health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 5 countries.

Peter MalocaOCTlab, Department of Ophthalmology, University Hospital of Basel, Basel, Switzerland.
Pascal W HaslerOCTlab, Department of Ophthalmology, University Hospital of Basel, Basel, Switzerland.
Daniel BarthelmesUniversity of Zurich, Department of Ophthalmology, University Hospital, Zurich, Switzerland.
Patrik ArnoldUniversity of Applied Sciences Engineering and Information Technology, Institute for Human Centered Engineering OptoLab, Biel/Berne, Switzerland.
Mooser MatthiasUniversity of Applied Sciences Engineering and Information Technology, Institute for Human Centered Engineering OptoLab, Biel/Berne, Switzerland.
Hendrik P N SchollInstitute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland.
Heinrich GerdingPallas Kliniken AG, Olten, Switzerland.
Justus GarwegBerner Augenklinik am Lindenhofspital and University of Bern, Bern, Switzerland.
Tjebo HeerenUniversity College London, Institute of Ophthalmology, London, UK.
Konstantinos BalaskasMoorfields Ophthalmic Reading Centre, London, UK.
J Emanuel Ramos de CarvalhoMoorfields Eye Hospital, London, UK.
Catherine EganMoorfields Eye Hospital, London, UK.
Adnan TufailMoorfields Eye Hospital, London, UK.
Sandrine A ZweifelUniversity of Zurich, Department of Ophthalmology, University Hospital, Zurich, Switzerland.
Moorfields Eye Hospital · GBUniversity College London · GBUniversity Hospital of Zurich · CHKantonsschule Olten · CHUniversity Hospital of Basel · CHUniversity of Basel · CHUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo study a novel and fast optical coherence tomography (OCT) device for home-based monitoring in age-related macular degeneration (AMD) in a small sample yielding sparse OCT (spOCT) data and to compare the device to a commercially available reference device.

methodsIn this prospective study, both eyes of 31 participants with AMD were included. The subjects underwent scanning with an OCT prototype and a spectral-domain OCT to compare the accuracy of the central retinal thickness (CRT) measurements.

resultsSixty-two eyes in 31 participants (21 females and 10 males) were included. The mean age was 79.6 years (age range, 69-92 years). The mean difference in the CRT measurements between the devices was 4.52 μm (SD ± 20.0 μm; range, -65.6 to 41.5 μm). The inter- and intrarater reliability coefficients of the OCT prototype were both >0.95. The laser power delivered was <0.54 mW for spOCT and <1.4 mW for SDOCT. No adverse events were reported, and the visual acuity before and after the measurements was stable.

conclusionThis study demonstrated the safety and feasibility of this home-based OCT monitoring under real-life conditions, and it provided evidence for the potential clinical benefit of the device. TRANSLATIONAL RELEVANCE: The newly developed spOCT is a valid and readily available retina scanner. It could be applied as a portable self-measuring OCT system. Its use may facilitate the sustainable monitoring of chronic retinal diseases by providing easily accessible and continuous retinal monitoring.

Indexed as

age-related macular degenerationmonitoringoptical coherence tomographyretina

Identifiers

PMID30050725
PMCPMC6058910
OpenAlexW2883849565

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.