Evidence map›Paper›PMID 30050647›Full record

ArticleOxidative medicine and cellular longevity2018

The Effect of Chronic NO Synthase Inhibition on the Vasoactive and Structural Properties of Thoracic Aorta, NO Synthase Activity, and Oxidative Stress Biomarkers in Young SHR.

Andrea Berenyiova, Ima Dovinova, Miroslava Kvandova, Frantisek Kristek, Eugene Jansen, Miroslava Majzunova, Sona Cacanyiova

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Endothelial Cell-Derived SOOxidative medicine and cellular longevity · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Andrea BerenyiovaInstitute of Normal and Pathological Physiology, Center of Experimental Medicine, Slovak Academy of Sciences, 813 71 Bratislava, Slovakia.
Ima DovinovaInstitute of Normal and Pathological Physiology, Center of Experimental Medicine, Slovak Academy of Sciences, 813 71 Bratislava, Slovakia.
Miroslava KvandovaInstitute of Normal and Pathological Physiology, Center of Experimental Medicine, Slovak Academy of Sciences, 813 71 Bratislava, Slovakia.
Frantisek KristekInstitute of Normal and Pathological Physiology, Center of Experimental Medicine, Slovak Academy of Sciences, 813 71 Bratislava, Slovakia.
Eugene JansenCentre for Health Protection, National Institute for Public Health and the Environment, 3721 MA Bilthoven, Netherlands.ORCID 0000-0002-3151-5897
Miroslava MajzunovaInstitute of Normal and Pathological Physiology, Center of Experimental Medicine, Slovak Academy of Sciences, 813 71 Bratislava, Slovakia.ORCID 0000-0001-8748-4279
Sona CacanyiovaInstitute of Normal and Pathological Physiology, Center of Experimental Medicine, Slovak Academy of Sciences, 813 71 Bratislava, Slovakia.ORCID 0000-0003-0483-7468
Slovak Academy of Sciences · SKNational Institute for Public Health and the Environment · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although the role of nitric oxide (NO) in essential hypertension is still unclear, the effects of long-term NO deficiency have not yet been investigated during the critical juvenile period in spontaneously hypertensive rats (SHR). We aimed to analyze the effects of chronic NO synthase (NOS) inhibition on systolic blood pressure (sBP), vasoactivity, morphological changes and superoxide level in the thoracic aorta (TA), NOS activity in different tissues, and general biomarkers of oxidative stress in plasma of young SHR. Four-week-old SHR were treated with N

Indexed as

AnimalsAorta, ThoracicBiomarkersBlood PressureHypertensionMaleNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide SynthaseOxidative StressRatsRats, Inbred SHRReactive Oxygen SpeciesVasodilationBiomarkersNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide SynthaseReactive Oxygen Species

Identifiers

PMID30050647
PMCPMC6046115
OpenAlexW2810771159

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.