ArticleFrontiers in physiology2018
Inactivation of Serotonergic Neurons in the Rostral Medullary Raphé Attenuates Stress-Induced Tachypnea and Tachycardia in Mice.
Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- CD38 connects the heart and brain.Translational psychiatry · 2025Review
- Hypoxia evokes a sequence of raphe-pontomedullary network operations for inspiratory drive amplification and gasping.Journal of neurophysiology · 2024Article
- Whole-brain analysis of CObioRxiv : the preprint server for biology · 2023Article
- Altered 5-HT2A/C receptor binding in the medulla oblongata in the sudden infant death syndrome (SIDS): Part I. Tissue-based evidence for serotonin receptor signaling abnormalities in cardiorespiratory- and arousal-related circuits.Journal of neuropathology and experimental neurology · 2023Article
- Activation of the rostral nucleus accumbens shell by optogenetics induces cataplexy-like behavior in orexin neuron-ablated mice.Scientific reports · 2023Article
- The physiological response during optogenetic-based cardiac pacing in awake freely moving mice.Frontiers in physiology · 2023Article
- Both Prelimbic and Infralimbic Noradrenergic Neurotransmissions Modulate Cardiovascular Responses to Restraint Stress in Rats.Frontiers in physiology · 2021Article
- Lateral Habenula Regulates Cardiovascular Autonomic ResponsesFrontiers in neuroscience · 2021Article
- Involvement of the Nucleus Accumbens in Chocolate-induced Cataplexy.Scientific reports · 2020Article
- Involvement of supralemniscal nucleus (B9) 5-HT neuronal system in nociceptive processing: a fiber photometry study.Molecular brain · 2020Article
- Serotonergic Modulation of Locomotor Activity From Basal Vertebrates to Mammals.Frontiers in neural circuits · 2020Review
- Acute nociceptive stimuli rapidly induce the activity of serotonin and noradrenalin neurons in the brain stem of awake mice.IBRO reports · 2019Article
- Blockade of 5-HT2A receptors inhibits emotional hyperthermia in mice.The journal of physiological sciences : JPS · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The medullary raphé nuclei are involved in controlling cardiovascular, respiratory, and thermoregulatory functions, as well as mediating stress-induced tachycardia and hyperthermia. Although the serotonergic system of the medullary raphé has been suggested as the responsible entity, specific evidence has been insufficient. In the present study, we tested this possibility by utilizing an optogenetic approach. We used genetically modified mice [tryptophan hydroxylase 2 (Tph2); archaerhodopsin-T (ArchT) mice] in which ArchT, a green light-driven neuronal silencer, was selectively expressed in serotonergic neurons under the regulation of Tph2 promoters. We first confirmed that an intruder stress selectively activated medullary, but not dorsal or median raphé serotonergic neurons. This activation was suppressed by photo-illumination via a pre-implanted optical fiber, as evidenced by the decrease of a cellular activation marker protein in the neurons. Next, we measured electro cardiogram (ECG), respiration, body temperature (BT), and locomotor activity in freely moving mice during intruder and cage-drop stress tests, with and without photo-illumination. In the intruder test, photo inactivation of the medullary serotonergic neurons significantly attenuated tachycardia (362 ± 58 vs. 564 ± 65 bpm.min,
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