ArticleFrontiers in human neuroscience2018
Effects of Repetition Learning on Associative Recognition Over Time: Role of the Hippocampus and Prefrontal Cortex.
Article in Frontiers in human neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
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- Salient Memory: Effects of Distributed Learning on Cortical Regions During Memory Retrieval.Human brain mapping · 2025Article
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- Identification of Reliable Target Brain Regions for Enhancing Object-Location Memory by Brain Stimulation.Brain and behavior · 2025Article
- Enhancing student understanding of cardiovascular disease burden in marginalized communities in the physiology classroom.Advances in physiology education · 2025Article
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- Interactive H5P content for increased student engagement in a dental hygiene program.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2024Article
- The influence of repeated study and repeated testing on the testing effect and the transfer effect over time.Memory & cognition · 2024Article
- The role of experience in prioritizing hippocampal replay.Nature communications · 2023Article
- Innovative e-Learning Training Modules to Improve Animal Welfare during Transport and Slaughter of Pigs: A Pretest-Posttest Study to Pre-Evaluate the General Didactical Concept.Animals : an open access journal from MDPI · 2023Article
- Memory capacity and prioritization in female mice.Scientific reports · 2023Article
- Forgetting of specific and gist visual associative episodic memory representations across time.Psychonomic bulletin & review · 2023Article
- Student knowledge gains among first-time and repeat attendees of school-based asthma education program.BMC pulmonary medicine · 2023Observational
- The Impact on Urology Residents' Learning of Social Media and Web Technologies after the Pandemic: A Step Forward through the Sharing of Knowledge.Healthcare (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
When stimuli are learned by repetition, they are remembered better and retained for a longer time. However, current findings are lacking as to whether the medial temporal lobe (MTL) and cortical regions are involved in the learning effect when subjects retrieve associative memory, and whether their activations differentially change over time due to learning experience. To address these issues, we designed an fMRI experiment in which face-scene pairs were learned once (L1) or six times (L6). Subjects learned the pairs at four retention intervals, 30-min, 1-day, 1-week and 1-month, after which they finished an associative recognition task in the scanner. The results showed that compared to learning once, learning six times led to stronger activation in the hippocampus, but weaker activation in the perirhinal cortex (PRC) as well as anterior ventrolateral prefrontal cortex (vLPFC). In addition, the hippocampal activation was positively correlated with that of the parahippocampal place area (PPA) and negatively correlated with that of the vLPFC when the L6 group was compared to the L1 group. The hippocampal activation decreased over time after L1 but remained stable after L6. These results clarified how the hippocampus and cortical regions interacted to support associative memory after different learning experiences.
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