Evidence map›Paper›PMID 30050382›Full record

ReviewDegenerative neurological and neuromuscular disease2017

Current concepts in multiple sclerosis therapy.

Leslie Sedal, Antony Winkel, Joshua Laing, Lai Yin Law, Elizabeth McDonald

Abstract readReview
In one paragraph

Review in Degenerative neurological and neuromuscular disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Observational
  5. Article
  6. The Cerebrospinal Fluid in Multiple Sclerosis.Frontiers in immunology · 2019
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Leslie SedalDepartment of Neurology, St Vincent's Hospital Melbourne, Melbourne, VIC, Australia, drlsedal@gmail.com.
Antony WinkelDepartment of Neurology, St Vincent's Hospital Melbourne, Melbourne, VIC, Australia, drlsedal@gmail.com.
Joshua LaingDepartment of Neurology, St Vincent's Hospital Melbourne, Melbourne, VIC, Australia, drlsedal@gmail.com.
Lai Yin LawDepartment of Neurology, St Vincent's Hospital Melbourne, Melbourne, VIC, Australia, drlsedal@gmail.com.
Elizabeth McDonaldDepartment of Neurology, St Vincent's Hospital Melbourne, Melbourne, VIC, Australia, drlsedal@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the past 20 years, the available therapies for multiple sclerosis have expanded exponentially. With several more agents likely to be approved for public funding in Australia in the next 12 months on top of the existing multitude of Australian Pharmaceutical Benefits Scheme-subsidized therapies, the choice is becoming even more complex. This review summarizes the current state of available therapies and anticipates likely future directions, including an important focus on contemporary symptom management. For each agent, the major trials, side effects, and clinical utility are summarized, with a particular focus on the Australian experience of these therapies. It is hoped this review provides an up-to-date reference of the exciting current state of multiple sclerosis therapy.

Indexed as

demyelinationdisease modifying drugsDMDsNEDAno evidence of disease activityPMLprogressive multifocal leukoencephalopathy

Identifiers

PMID30050382
PMCPMC6053095

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.