ArticleThe ISME journal2018
Genomic profiling of four cultivated Candidatus Nitrotoga spp. predicts broad metabolic potential and environmental distribution.
Article in The ISME journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Bioremediation of Saline-Alkali Soil Using a Waste Biomass-Functional Microorganism Composite Amendment and Preliminary Multi-Crop Field Validation.Microorganisms · 2026Article
- Kinetic plasticity of nitrite-oxidizing bacteria containing cytoplasmic nitrite oxidoreductase.The ISME journal · 2026Article
- Overcoming gelling agent-derived inhibitory factors enables the cultivation of fastidious nitrifiers on solid media.ISME communications · 2026Article
- Seagrass-derived carbon suppresses nitrification and NISME communications · 2026Article
- Cultivation and metabolic versatility of novel and ubiquitous chemolithoautotrophicMicrobiology spectrum · 2025Article
- 236 metagenome-assembled microbial genomes from rivers along a latitudinal gradient.Scientific data · 2025Article
- Genetic isolation and metabolic complexity of an Antarctic subglacial microbiome.Nature communications · 2025Article
- Abundant and metabolically flexible bacterial lineages underlie a vast potential for rubisco-mediated carbon fixation in the dark ocean.Genome biology · 2025Article
- Analysis of microbiome high-dimensional experimental design data using generalized linear models and ANOVA simultaneous component analysis.Frontiers in microbiomes · 2025Article
- Article
- Metabolic capacity is maintained despite shifts in microbial diversity in estuary sediments.ISME communications · 2025Article
- Microbiome structure and function in parallel full-scale aerobic granular sludge and activated sludge processes.Applied microbiology and biotechnology · 2024Article
- An abundant bacterial phylum with nitrite-oxidizing potential in oligotrophic marine sediments.Communications biology · 2024Article
- Diversity and distribution of iron-oxidising bacteria belonging to Gallionellaceae in different sites of a hydroelectric power plant.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Vertical Distribution and Seasonal Patterns of Candidatus Nitrotoga in a Sub-Alpine Lake.Microbes and environments · 2024Article
- Gallionellaceae pangenomic analysis reveals insight into phylogeny, metabolic flexibility, and iron oxidation mechanisms.mSystems · 2023Article
- Nitrite Oxidation in Wastewater Treatment: Microbial Adaptation and Suppression Challenges.Environmental science & technology · 2023Review
- Article
- Effects of Co-existing Heterotrophs on Physiology of and Nitrogen Metabolism in Autotrophic Nitrite-oxidizing Candidatus Nitrotoga.Microbes and environments · 2023Article
- Genome Streamlining, Proteorhodopsin, and Organic Nitrogen Metabolism in Freshwater Nitrifiers.mBio · 2022Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitrite-oxidizing bacteria (NOB) play a critical role in the mitigation of nitrogen pollution by metabolizing nitrite to nitrate, which is removed via assimilation, denitrification, or anammox. Recent studies showed that NOB are phylogenetically and metabolically diverse, yet most of our knowledge of NOB comes from only a few cultured representatives. Using cultivation and genomic sequencing, we identified four putative Candidatus Nitrotoga NOB species from freshwater sediments and water column samples in Colorado, USA. Genome analyses indicated highly conserved 16S rRNA gene sequences, but broad metabolic potential including genes for nitrogen, sulfur, hydrogen, and organic carbon metabolism. Genomic predictions suggested that Ca. Nitrotoga can metabolize in low oxygen or anoxic conditions, which may support an expanded environmental niche for Ca. Nitrotoga similar to other NOB. An array of antibiotic and metal resistance genes likely allows Ca. Nitrotoga to withstand environmental pressures in impacted systems. Phylogenetic analyses highlighted a deeply divergent nitrite oxidoreductase alpha subunit (NxrA), suggesting a novel evolutionary trajectory for Ca. Nitrotoga separate from any other NOB and further revealing the complex evolutionary history of nitrite oxidation in the bacterial domain. Ca. Nitrotoga-like 16S rRNA gene sequences were prevalent in globally distributed environments over a range of reported temperatures. This work considerably expands our knowledge of the Ca. Nitrotoga genus and suggests that their contribution to nitrogen cycling should be considered alongside other NOB in wide variety of habitats.
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