ArticleScientific reports2018
Small litter size impairs spatial memory and increases anxiety- like behavior in a strain-dependent manner in male mice.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 48 citations in OpenAlex.
- Behavioral impact of adolescent social isolation stress: A multidimensional assessment in male NMRI mice.Learning & behavior · 2026Article
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- Early life exposure to high fructose diet induces metabolic dysregulation associated with sex-specific cognitive impairment in adolescent rats.The Journal of nutritional biochemistry · 2023Article
- Genetic Background Influence on Hippocampal Synaptic Plasticity: Frequency-Dependent Variations between an Inbred and an Outbred Mice Strain.International journal of molecular sciences · 2023Article
- Sources and Translational Relevance of Heterogeneity in Maternal Immune Activation Models.Current topics in behavioral neurosciences · 2023Review
- Using Appetitive Motivation to Train Mice for Spatial Learning in the Barnes Maze.BioMed research international · 2023Article
- Hypothalamic NR3C1 DNA methylation in rats exposed to prenatal stress.Molecular biology reports · 2022Article
- Review
- Controlling litter effects to enhance rigor and reproducibility with rodent models of neurodevelopmental disorders.Journal of neurodevelopmental disorders · 2021Review
- Serotonin 5-HT1A receptors modulate depression-related symptoms following mild traumatic brain injury in male adult mice.Metabolic brain disease · 2019Article
- Minocycline prevents the development of depression-like behavior and hippocampal inflammation in a rat model of Alzheimer's disease.Psychopharmacology · 2019Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early life overfeeding is associated with cognitive decline and anxiety-like behaviors in later life. It is not clear whether there are individual differences in the effects of early life overfeeding and what the underlying mechanistic pathways are. We investigated the long-lasting effects of small litter size, an experimental manipulation to induce neonatal overfeeding, in two strains of mice, C57BL/6 and NMRI. We measured body weight, learning and memory, anxiety-related behaviors, interleukin-(IL)-1β and brain-derived-neurotrophic-factor (BDNF) levels in the hippocampus, and both basal and stress corticosterone levels in adult mice which have been nursed in small litters compared with those from control litters. Our findings showed that small litter size led to increased body weight in both strains of mice. Small litter size significantly decreased spatial memory and hippocampal BDNF levels, and increased hippocampal IL-1β, in NMRI mice, but not C57BL/6 mice. Interestingly, we found that small litter size resulted in a significant increase in anxiety-like behaviors and stress-induced corticosterone in NMRI mice, whereas small litter size reduced anxiety-like symptoms and stress-induced corticosterone levels in C57BL/6 mice. These data show that small litter size, which is life-long associated with increased body weight, affects memory and anxiety-related behaviors in a strain-dependent manner in male mice. This suggests that there are individual differences in the developmental consequences of early life overfeeding.
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