ArticleScientific reports2018
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Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- A Rare Noncoding Enhancer Variant inCirculation · 2025Article
- The Role of Human-Induced Pluripotent Stem Cells in Studying Cardiac Channelopathies.International journal of molecular sciences · 2024Review
- iPSC-cardiomyocytes in the preclinical prediction of candidate pharmaceutical toxicity.Frontiers in pharmacology · 2024Review
- Review
- HiPSC-derived cardiomyocyte to model Brugada syndrome: both asymptomatic and symptomatic mutation carriers reveal increased arrhythmogenicity.BMC cardiovascular disorders · 2023Article
- Automated Patch-Clamp and Induced Pluripotent Stem Cell-Derived Cardiomyocytes: A Synergistic Approach in the Study of Brugada Syndrome.International journal of molecular sciences · 2023Review
- Maturation of hiPSC-derived cardiomyocytes promotes adult alternative splicing of SCN5A and reveals changes in sodium current associated with cardiac arrhythmia.Cardiovascular research · 2023Article
- iPSC-Derived Cardiomyocytes in Inherited Cardiac Arrhythmias: Pathomechanistic Discovery and Drug Development.Biomedicines · 2023Review
- Injection of IFrontiers in physiology · 2023Article
- Brugada Syndrome: Different Experimental Models and the Role of Human Cardiomyocytes From Induced Pluripotent Stem Cells.Journal of the American Heart Association · 2022Review
- Contributions of NaScientific reports · 2021Article
- Review
- Patient-specific induced pluripotent stem cells as "disease-in-a-dish" models for inherited cardiomyopathies and channelopathies - 15 years of research.World journal of stem cells · 2021Review
- iPSC-Cardiomyocyte Models of Brugada Syndrome-Achievements, Challenges and Future Perspectives.International journal of molecular sciences · 2021Review
- Mechanisms of Arrhythmias in the Brugada Syndrome.International journal of molecular sciences · 2020Review
- Genetic basis and molecular biology of cardiac arrhythmias in cardiomyopathies.Cardiovascular research · 2020Review
- Human Induced Pluripotent Stem Cells Derived from a Cardiac Somatic Source: Insights for an In-Vitro Cardiomyocyte Platform.International journal of molecular sciences · 2020Review
- Disease Phenotypes and Mechanisms of iPSC-Derived Cardiomyocytes From Brugada Syndrome Patients With a Loss-of-Function SCN5A Mutation.Frontiers in cell and developmental biology · 2020Article
- Electrophysiological Abnormalities in VLCAD Deficient hiPSC-Cardiomyocytes Do not Improve with Carnitine Supplementation.Frontiers in pharmacology · 2020Article
- Comparing human iPSC-cardiomyocytes versus HEK293T cells unveils disease-causing effects of Brugada mutation A735V of NaScientific reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 6 institutions in 4 countries.
Dongrui MaNational Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, 169609, Republic of Singapore.ORCID 0000-0003-1024-1660
Zhenfeng LiuNational Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, 169609, Republic of Singapore.
Li Jun LohNational Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, 169609, Republic of Singapore.
Yongxing ZhaoNational Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, 169609, Republic of Singapore.
Guang LiNational Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, 169609, Republic of Singapore.
Reginald LiewCardiovascular & Metabolic Disorders Program, Duke-NUS Medical School Singapore, Singapore, 169857, Republic of Singapore.
Omedul IslamNational Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, 169609, Republic of Singapore.
Jianjun WuNational Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, 169609, Republic of Singapore.
Ying Ying ChungNational Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, 169609, Republic of Singapore.
Wee Siong TeoDepartment of Cardiology, National Heart Centre Singapore, Singapore, 169609, Republic of Singapore.
Chi Keong ChingDepartment of Cardiology, National Heart Centre Singapore, Singapore, 169609, Republic of Singapore.
Boon Yew TanDepartment of Cardiology, National Heart Centre Singapore, Singapore, 169609, Republic of Singapore.
Daniel ChongDepartment of Cardiology, National Heart Centre Singapore, Singapore, 169609, Republic of Singapore.
Kah Leng HoDepartment of Cardiology, National Heart Centre Singapore, Singapore, 169609, Republic of Singapore.
Paul LimDepartment of Cardiology, National Heart Centre Singapore, Singapore, 169609, Republic of Singapore.
Rita Yu Yin YongDefense Medical and Environmental Research Institute, DSO National Laboratories, Singapore, 117510, Republic of Singapore.ORCID 0000-0002-9770-6565
Brian K PanamaUniversity at Buffalo, State University of New York, Buffalo, NY, 14214, USA.
Aaron D KaplanUniversity at Buffalo, State University of New York, Buffalo, NY, 14214, USA.
Glenna C L BettUniversity at Buffalo, State University of New York, Buffalo, NY, 14214, USA.
James WareImperial College London, South Kensington Campus, London, SW7 2AZ, UK.ORCID 0000-0002-6110-5880
Connie R BezzinaAcademic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Arie O VerkerkAcademic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Stuart A CookNational Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, 169609, Republic of Singapore.
Randall L RasmussonUniversity at Buffalo, State University of New York, Buffalo, NY, 14214, USA. rr32@buffalo.edu.
Heming WeiNational Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, 169609, Republic of Singapore. heming_wei@yahoo.com.
National Heart Centre Singapore · SGUniversity at Buffalo, State University of New York · USDuke-NUS Medical School · SGAmsterdam UMC Location University of Amsterdam · NLDSO National Laboratories · SGImperial College London · GB
Funding
Medical Research Council MC_UP_1102/20MOH | National Medical Research Council (NMRC) CG12Aug09MOH | National Medical Research Council (NMRC) STaR/011/2012
Abstract
Brugada syndrome (BrS) is an inherited cardiac arrhythmia commonly associated with SCN5A mutations, yet its ionic mechanisms remain unclear due to a lack of cellular models. Here, we used human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) from a BrS patient (BrS1) to evaluate the roles of Na
Indexed as
Membrane PotentialsBrugada SyndromeCell DifferentiationHumansMutationMyocytes, CardiacNAV1.5 Voltage-Gated Sodium ChannelPatch-Clamp TechniquesPluripotent Stem CellsPotassiumSodiumNAV1.5 Voltage-Gated Sodium ChannelPotassiumSCN5A protein, humanSodium
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.