Evidence map›Paper›PMID 30050088›Full record

ArticleNature communications2018

Digital acoustofluidics enables contactless and programmable liquid handling.

Steven Peiran Zhang, James Lata, Chuyi Chen, John Mai, Feng Guo, Zhenhua Tian, Liqiang Ren, Zhangming Mao, Po-Hsun Huang, Peng Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Droplet Digital CRISPR for Nucleic Acid Detection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Steven Peiran ZhangDepartment of Mechanical Engineering and Material Science, Duke University, Durham, NC, 27708, USA.
James LataDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University Park, State College, PA, 16802, USA.
Chuyi ChenDepartment of Mechanical Engineering and Material Science, Duke University, Durham, NC, 27708, USA.
John MaiAlfred E. Mann Institute for Biomedical Engineering, University of Southern California, Los Angeles, CA, 90007, USA.
Feng GuoDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University Park, State College, PA, 16802, USA.
Zhenhua TianDepartment of Mechanical Engineering and Material Science, Duke University, Durham, NC, 27708, USA.
Liqiang RenDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University Park, State College, PA, 16802, USA.
Zhangming MaoDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University Park, State College, PA, 16802, USA.
Po-Hsun HuangDepartment of Mechanical Engineering and Material Science, Duke University, Durham, NC, 27708, USA.ORCID http://orcid.org/0000-0001-9600-0141
Peng LiDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University Park, State College, PA, 16802, USA.
Shujie YangDepartment of Mechanical Engineering and Material Science, Duke University, Durham, NC, 27708, USA.
Tony Jun HuangDepartment of Mechanical Engineering and Material Science, Duke University, Durham, NC, 27708, USA. tony.huang@duke.edu.ORCID http://orcid.org/0000-0003-1205-3313

Funding

Standing Surface Acoustic Wave Based Cell Sorters for Maintaining Cell IntegrityR01GM112048 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI HUANG, TONY JUN · 2014 to 2017
$1.1M
Validation of acoustic tweezers for single-cell analyses of purine metabolismR33EB019785 · NIBIB · PENNSYLVANIA STATE UNIVERSITY, THE · PI HUANG, TONY JUN · 2014 to 2016
$1.1M
Center for Hierarchical Manufacturing, National Science Foundation (Center for Hierarchical Manufacturing) CBET-1438126Center for Hierarchical Manufacturing, National Science Foundation (Center for Hierarchical Manufacturing) IDBR-1455658NIBIB NIH HHS R33 EB019785NIGMS NIH HHS R01 GM112048U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01 GM112048U.S. Department of Health & Human Services | National Institutes of Health (NIH) R33 EB019785
6 · The paper itself

Abstract

For decades, scientists have pursued the goal of performing automated reactions in a compact fluid processor with minimal human intervention. Most advanced fluidic handling technologies (e.g., microfluidic chips and micro-well plates) lack fluid rewritability, and the associated benefits of multi-path routing and re-programmability, due to surface-adsorption-induced contamination on contacting structures. This limits their processing speed and the complexity of reaction test matrices. We present a contactless droplet transport and processing technique called digital acoustofluidics which dynamically manipulates droplets with volumes from 1 nL to 100 µL along any planar axis via acoustic-streaming-induced hydrodynamic traps, all in a contamination-free (lower than 10

Indexed as

AcousticsHumansHydrodynamicsMicrofluidic Analytical TechniquesMicrofluidics

Identifiers

PMID30050088
PMCPMC6062562

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.