Evidence map›Paper›PMID 30050075›Full record

SynthesisEuropean journal of clinical nutrition2019

Dietary patterns derived from principal component analysis (PCA) and risk of colorectal cancer: a systematic review and meta-analysis.

Vanessa Garcia-Larsen, Victoria Morton, Teresa Norat, André Moreira, James F Potts, Tim Reeves, Ioannis Bakolis

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European journal of clinical nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05732623 (Diet obEsity sMoking Epigenetics geneTics biomaRkers Physical Activity), which is not on this map. Cited by 54 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 6 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05732623 recruitingnot on this mapstarted 2022, after this paper: background citation

Diet obEsity sMoking Epigenetics geneTics biomaRkers Physical Activity: An International Multicenter Case-control Study on Endogenous and Exogenous Risk Factors in Early-onset Colorectal Cancer

Typeobservational_patient_registrySponsorSan Raffaele UniversityRan2022 to 2035Enrolled2,300ConditionsColorectal Cancer, Early Onset Colorectal Cancer, Diet Habit, Risk ReductionArmsSemi Quantitative Food Frequency Questionnaire (SQFFQ)
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 6 syntheses or guidelines pooled it, 103 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Vanessa Garcia-Larsen2 Program in Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA. vgla@jhu.edu.ORCID 0000-0002-0003-1988
Victoria MortonSchool of Public Health, Imperial College London, London, UK.
Teresa NoratSchool of Public Health, Imperial College London, London, UK.
André MoreiraImmuno-allergology, Hospital São João & Immunology, Faculty of Medicine, University of Porto, Porto, Portugal.
James F PottsPopulation Health and Occupational Medicine Group, National Heart and Lung Institute, Imperial College London, London, UK.
Tim ReevesNational Guideline Alliance (NGA), Royal College of Obstetricians and Gynaecologists, London, UK.
Ioannis BakolisDepartment of Biostatistics and Health Informatics, Kings College London, London, UK.
Imperial College London · GBJohns Hopkins University · USKing's College London · GBRoyal College of Obstetricians and Gynaecologists · GBUniversidade do Porto · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimColorectal cancer (CRC) is highly prevalent worldwide, with dietary habits being a major risk factor. We systematically reviewed and meta-analysed the observational evidence on the association between CRC and dietary patterns (DP) derived from principal component analysis.

designPRISMA guidelines were followed. Web of Science, Medline/PubMed, EMBASE, and The Cochrane Library were searched to identify all eligible papers published up to the 31st July 2017. Any pre-defined cancer of the colon was included, namely colon-rectal cancer (CRC), colon cancer (CC), rectal cancer (RC), or proximal and distal CC, if available. Western (WDP) and prudent (PDP) dietary patterns were compared as a proxy to estimate "unhealthy" (Rich in meat and processed foods) and "healthy" diets (containing fruits or vegetables), respectively. Meta-analyses were carried out using random effects model to calculate overall risk estimates. Relative risks (RR) and 95% confidence intervals were estimated comparing the highest versus the lowest categories of dietary patterns for any of the forms of colon cancer studied.

results28 studies were meta-analysed. A WDP was associated with increased risk of CRC (RR 1.25; 95% CI 1.11, 1.40), and of CC (RR 1.30; 95% CI 1.11, 1.52). A PDP was negatively associated with CRC (RR 0.81; 95% CI 0.73, 0.91). Sensitivity analyses showed that individuals from North-and South-American countries had a significantly higher risk of CRC than those from other continents.

conclusionA PDP might reduce the risk of CRC. Conversely, a WDP is associated with a higher risk of disease.

Indexed as

Colorectal NeoplasmsDietHumansPrincipal Component AnalysisRisk Assessment

Identifiers

PMID30050075
OpenAlexW2884097207

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.