Evidence map›Paper›PMID 30050055›Full record

ArticleCell death and differentiation2019

Activation of S6 signaling is associated with cell survival and multinucleation in hyperplastic skin after epidermal loss of AURORA-A Kinase.

Weston Kenneth Ryan, Josiah Fernandez, Mikayla Katherine Peterson, David William Sheneman, Brendan Keefe Podell, Subhajyoti De, Enrique Carlo Torchia

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death and differentiation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 16 citations in OpenAlex.

  1. Polyploidy and mTOR signaling: a possible molecular link.Cell communication and signaling : CCS · 2024
    Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Weston Kenneth RyanDepartment of Dermatology and the Gates Center for Regenerative Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Josiah FernandezDepartment of Dermatology and the Gates Center for Regenerative Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Mikayla Katherine PetersonDepartment of Dermatology and the Gates Center for Regenerative Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
David William ShenemanDepartment of Dermatology and the Gates Center for Regenerative Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Brendan Keefe PodellMicrobiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
Subhajyoti DeRutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA.
Enrique Carlo TorchiaDepartment of Dermatology and the Gates Center for Regenerative Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Enrique.Torchia@ucdenver.edu.
University of Colorado Anschutz Medical Campus · USColorado State University · USGates (United States) · USRutgers, The State University of New Jersey · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Transgenic and Gene Targeting CoreP30AR057212 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI NORRIS, DAVID A. · 2009 to 2018
$6.2M
NCI NIH HHS P30 CA046934NIAMS NIH HHS P30 AR057212
6 · The paper itself

Abstract

The role of mitosis in the progression of precancerous skin remains poorly understood. To address this question, we deleted the mitotic Kinase Aurora-A (Aur-A) in hyperplastic mutant p53 mouse skin as an experimental tool to study the G2/M transition in precancerous keratinocytes and AUR-A's role in this process. Epidermal Aur-A deletion (Aur-A

Indexed as

AnimalsAurora Kinase ACarcinoma, Squamous CellCell Line, TumorCell SurvivalHumansMiceMice, TransgenicRibosomal Protein S6 KinasesSignal TransductionSkin NeoplasmsAURKA protein, humanAurka protein, mouseAurora Kinase ARibosomal Protein S6 Kinases

Identifiers

PMID30050055
PMCPMC6370802
OpenAlexW2884257041

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.