ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2018
Role of gamma-amino-butyric acid in the dorsal anterior cingulate in age-associated changes in cognition.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Meta-analysis and open-source database for in vivo brain Magnetic Resonance spectroscopy in health and disease.Analytical biochemistry · 2023Pooled it
- Pooled it
- Effects of High Definition-Transcranial Direct Current Stimulation on Local GABA and Glutamate Levels Among Older Adults with and without Mild Cognitive Impairment: An Exploratory Study.Journal of Alzheimer's disease : JAD · 2021Trial
- The effect of growth hormone-releasing hormone on cognition and brain connectivity in adults with cognition ranging from normal to mild cognitive impairment.eNeurologicalSci · 2026Article
- Cognitive engagement induces area-specific fingerprints of dopamine, acetylcholine, serotonin, glutamate and GABA in prefrontal cortex and striatum.bioRxiv : the preprint server for biology · 2026Article
- Myo-Inositol Levels in the Dorsal Anterior Cingulate Cortex Are Associated With Anxiety-to-Eat in Anorexia Nervosa.The International journal of eating disorders · 2026Article
- Changes in the cortical GABAergic inhibitory system with ageing and ageing-related neurodegenerative diseases.The Journal of physiology · 2026Review
- Neurochemical changes in GABA+, Glx, and the excitatory/inhibitory ratio in the calcarine cortex with healthy aging.NeuroImage · 2025Article
- Hippocampal and prefrontal GABA and glutamate concentration contribute to component processes of working memory in aging.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- GABA, Glx, and GSH in the cerebellum: their role in motor performance and learning across age groups.Frontiers in aging neuroscience · 2025Article
- Association between Inhibitory-Excitatory Balance and Brain Activity Response during Cognitive Flexibility in Young and Older Individuals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Early-life differences in the gut microbiota composition and functionality of infants at elevated likelihood of developing autism spectrum disorder.Translational psychiatry · 2023Article
- Meta-analysis and Open-source Database for In Vivo Brain Magnetic Resonance Spectroscopy in Health and Disease.bioRxiv : the preprint server for biology · 2023Article
- A comprehensive guide to MEGA-PRESS for GABA measurement.Analytical biochemistry · 2023Review
- Decreased GABA+ Levels in the Medial Prefrontal Cortex of Perimenopausal Women: A 3T 1H-MRS Study.The international journal of neuropsychopharmacology · 2023Article
- The Effects of Gamma-Aminobuytric Acid (GABA) Enrichment on Nutritional, Physical, Shelf-Life, and Sensorial Properties of Dark Chocolate.Foods (Basel, Switzerland) · 2023Article
- Decreased GABA levels of the anterior and posterior cingulate cortex are associated with executive dysfunction in mild cognitive impairment.Frontiers in neuroscience · 2023Article
- The interaction between endogenous GABA, functional connectivity, and behavioral flexibility is critically altered with advanced age.Communications biology · 2022Article
- The association between language-based task-functional magnetic resonance imaging hemodynamics and baseline GABA+ and glutamate-glutamine measured in pre-supplementary motor area: A pilot study in an aging model.Frontiers in psychiatry · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
GABAergic mechanisms have been shown to contribute to cognitive aging in animal models, but there is currently limited in vivo evidence to support this relationship in humans. It is also unclear whether aging is associated with changes in GABA levels measured with proton magnetic resonance spectroscopy (MRS). Spectral-editing MRS at 3 T was used to measure GABA in the dorsal anterior cingulate cortex (dACC) for a large sample of healthy volunteers (N = 229) aged 18-55. In a subset of 171 participants, age effects on several cognitive tasks were studied. We formally tested whether the MRS measures mediated the relationship between age and cognition. Robust associations of age with performance were found for the Wisconsin Card Sorting Test ([WCST], p < 0.0001). Age was also significantly associated with declining levels of GABA in the dACC (p < 0.001), and GABA levels significantly predicted WCST performance (p < 0.0004). Mediation analysis revealed that GABA in the dACC mediated the effect of age on WCST performance (p < 0.01). Other metabolites were similarly associated with age, but only GABA and creatine levels were significantly associated with WCST performance. No association with age or cognitive performance was found in a frontal white matter control region in a subset of participants. The association of GABA with WCST performance was not related to the amount of brain atrophy associated with aging as measured by the proportion of CSF, gray, and white matter in the MRS voxel. These results implicate GABAergic and possibly energetic metabolism in the dACC as mechanisms of age effects in executive function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.