Evidence map›Paper›PMID 30050041›Full record

ArticleScientific reports2018

Involvement of median preoptic nucleus and medullary noradrenergic neurons in cardiovascular and sympathetic responses of hemorrhagic rats.

Lara Marques Naves, Stefanne Madalena Marques, Aline Andrade Mourão, James Oluwagbamigbe Fajemiroye, Carlos Henrique Xavier, Carlos Henrique de Castro, Ana Cristina Silva Rebelo, Daniel Alves Rosa, Rodrigo Mello Gomes, Eduardo Colombari and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Lara Marques NavesDepartamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Estrada do Campus, s/n, 74690-900, Goiânia, GO, Brazil.
Stefanne Madalena MarquesDepartamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Estrada do Campus, s/n, 74690-900, Goiânia, GO, Brazil.
Aline Andrade MourãoDepartamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Estrada do Campus, s/n, 74690-900, Goiânia, GO, Brazil.
James Oluwagbamigbe FajemiroyeFaculdade de Farmácia, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.
Carlos Henrique XavierDepartamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Estrada do Campus, s/n, 74690-900, Goiânia, GO, Brazil.ORCID 0000-0003-4006-8213
Carlos Henrique de CastroDepartamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Estrada do Campus, s/n, 74690-900, Goiânia, GO, Brazil.
Ana Cristina Silva RebeloDepartamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Estrada do Campus, s/n, 74690-900, Goiânia, GO, Brazil.
Daniel Alves RosaDepartamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Estrada do Campus, s/n, 74690-900, Goiânia, GO, Brazil.
Rodrigo Mello GomesDepartamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Estrada do Campus, s/n, 74690-900, Goiânia, GO, Brazil.
Eduardo ColombariDepartamento de Fisiologia e Patologia, Faculdade de odontologia, Universidade Estadual Paulista, Araraquara, São Paulo, Brazil.
Gustavo Rodrigues PedrinoDepartamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Estrada do Campus, s/n, 74690-900, Goiânia, GO, Brazil. pedrino@ufg.br.
Universidade Federal de Goiás · BRUniversidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The infusion of hypertonic saline solution (HSS) is known to be beneficial to the treatment of hypovolemic hemorrhage (HH). The central mechanism of HSS-induced cardiovascular and autonomic recovery of animals subjected to HH remains unclear. Hence, the present study evaluated the involvement of median preoptic nucleus (MnPO) and medullary noradrenergic neurons (A1 and A2) in HSS-induced cardiovascular and sympathetic responses in hemorrhagic rats. The wistar rats were subjected to specific lesion of noradrenergic neurons through the nanoinjections of anti-DβH-saporin into caudal ventrolateral medulla (A1 neurons) and nucleus of the solitary tract (A2 neurons). After recovery, mean arterial pressure (MAP) and renal sympathetic nervous activity were recorded. The HH was performed through blood withdrawal until a MAP of 60 mmHg was attained. In sham rats, HSS infusion (3M NaCl) reestablished MAP without change in HH-induced sympathoinhibition. The muscimol (agonist of GABA

Indexed as

Adaptation, PhysiologicalCardiovascular Physiological PhenomenaAdrenergic NeuronsAnimalsArterial PressureHemorrhagePreoptic AreaRats, WistarSympathetic Nervous System

Identifiers

PMID30050041
PMCPMC6062576
OpenAlexW2883780185

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.