Evidence map›Paper›PMID 30050035›Full record

ArticleCell death & disease2018

Oxidation of KCNB1 channels in the human brain and in mouse model of Alzheimer's disease.

Yu Wei, Mi Ryung Shin, Federico Sesti

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
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  5. Review
  6. The Polypharmacological Effects of Cannabidiol.Molecules (Basel, Switzerland) · 2023
    Review
  7. Article
  8. Review
  9. Review
  10. Increased KCells · 2022
    Article
  11. Article
  12. Antagonistic roles of Ras-MAPK and Akt signaling in integrin-KFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Complexes formed with integrin-α5 and KCNB1 potassium channel wild type or epilepsy-susceptibility variants modulate cellular plasticityFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  18. Defining the Kv2.1-syntaxin molecular interaction identifies a first-in-class small molecule neuroprotectant.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yu WeiDepartment of Neuroscience and Cell Biology, Rutgers University Robert Wood Johnson Medical School, 683 Hoes Lane West, Piscataway, NJ, 08854, USA.
Mi Ryung ShinDepartment of Neuroscience and Cell Biology, Rutgers University Robert Wood Johnson Medical School, 683 Hoes Lane West, Piscataway, NJ, 08854, USA.
Federico SestiDepartment of Neuroscience and Cell Biology, Rutgers University Robert Wood Johnson Medical School, 683 Hoes Lane West, Piscataway, NJ, 08854, USA. federico.sesti@rutgers.edu.ORCID 0000-0002-2761-9693
Rutgers, The State University of New Jersey · US

Funding

Oxidation of K+ channels mediates an amyloidogenic pathway common to Alzheimer's disease and TBIR01AG060919 · NIA · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI SESTI, FEDERICO · 2019 to 2023
$2.0M
Oxidative modification of K+ channels as a mechanism of toxicity in TBIR21NS096619 · NINDS · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI SESTI, FEDERICO · 2016 to 2017
$432k
NIA NIH HHS R01 AG060919NINDS NIH HHS R21 NS096619
6 · The paper itself

Abstract

Oxidative modification of the voltage-gated K

Indexed as

Aged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesAnimalsBrainDasatinibDisease Models, AnimalFemaleFocal Adhesion Kinase 1GliosisHumansMaleMemory, Short-TermMiceMice, TransgenicOxidative StressAmyloid beta-PeptidesDasatinibFocal Adhesion Kinase 1KCNB1 protein, humanShab Potassium Channelssrc-Family Kinases

Identifiers

PMID30050035
PMCPMC6062629
OpenAlexW2884887758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.