Evidence map›Paper›PMID 30050028›Full record

ReviewGenes2018

Blueprints for Biosensors: Design, Limitations, and Applications.

Alexander C Carpenter, Ian T Paulsen, Thomas C Williams

Abstract readReview
In one paragraph

Review in Genes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Disentangling the Regulatory Response ofACS synthetic biology · 2024
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. A concise overview of advancements in ultrasensitive biosensor development.Frontiers in bioengineering and biotechnology · 2023
    Review
  16. Review
  17. Transcription factor-based biosensors for screening and dynamic regulation.Frontiers in bioengineering and biotechnology · 2023
    Review
  18. Article
  19. Screening microbially produced ΔNature communications · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alexander C CarpenterDepartment of Molecular Sciences, Macquarie University, Sydney, NSW 2109, Australia. alexander.charles.carpenter@gmail.com.
Ian T PaulsenDepartment of Molecular Sciences, Macquarie University, Sydney, NSW 2109, Australia. ian.paulsen@mq.edu.au.
Thomas C WilliamsDepartment of Molecular Sciences, Macquarie University, Sydney, NSW 2109, Australia. tom.williams@mq.edu.au.ORCID 0000-0002-0594-3441

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biosensors are enabling major advances in the field of analytics that are both facilitating and being facilitated by advances in synthetic biology. The ability of biosensors to rapidly and specifically detect a wide range of molecules makes them highly relevant to a range of industrial, medical, ecological, and scientific applications. Approaches to biosensor design are as diverse as their applications, with major biosensor classes including nucleic acids, proteins, and transcription factors. Each of these biosensor types has advantages and limitations based on the intended application, and the parameters that are required for optimal performance. Specifically, the choice of biosensor design must consider factors such as the ligand specificity, sensitivity, dynamic range, functional range, mode of output, time of activation, ease of use, and ease of engineering. This review discusses the rationale for designing the major classes of biosensor in the context of their limitations and assesses their suitability to different areas of biotechnological application.

Indexed as

analyticsaptamersbiosensorshigh-throughput screeningmetabolic engineeringmolecular diagnosticsprotein switchessynthetic biology

Identifiers

PMID30050028
PMCPMC6115959

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.