Evidence map›Paper›PMID 30049972›Full record

ReviewViruses2018

Redox Biology of Respiratory Viral Infections.

Olga A Khomich, Sergey N Kochetkov, Birke Bartosch, Alexander V Ivanov

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04748172 (The Effect of COVID -19 mRNA Vaccine on Ovarian Reserve), which is not on this map. Cited by 224 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
224citing papers in PubMed, 2 pooled it
18.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04748172 completednot on this mapstarted 2021, after this paper: background citation

The Effect of COVID -19 mRNA Vaccine on Ovarian Reserve

TypeobservationalSponsorSheba Medical CenterRan2021 to 2023Enrolled200ConditionsFertility Issues, Vaccine Adverse ReactionArmsSARS-CoV-2 virus vaccines, AMH sampling, anti Covid-19 antibody levels (Serology)
3 · Its place in the literature

Who cites it

224 citing papers in PubMed, 2 syntheses or guidelines pooled it, 388 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Integrated Evaluation ofPharmaceuticals (Basel, Switzerland) · 2026
    Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Food science & nutrition · 2025
    Review
  12. Article
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  16. Article
  17. Review
  18. Article
  19. Review
  20. Article

164 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Olga A KhomichEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str, 32, 119991 Moscow, Russia. o.a.khomich@gmail.com.
Sergey N KochetkovEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str, 32, 119991 Moscow, Russia. kochet@eimb.ru.
Birke BartoschInserm U1052, Cancer Research Center Lyon, University of Lyon, 69000 Lyon, France. birke.bartosch@inserm.fr.ORCID 0000-0001-6354-4660
Alexander V IvanovEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str, 32, 119991 Moscow, Russia. aivanov@yandex.ru.ORCID 0000-0002-5659-9679
Engelhardt Institute of Molecular Biology · RUUniversité Claude Bernard Lyon 1 · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Respiratory viruses cause infections of the upper or lower respiratory tract and they are responsible for the common cold-the most prevalent disease in the world. In many cases the common cold results in severe illness due to complications, such as fever or pneumonia. Children, old people, and immunosuppressed patients are at the highest risk and require fast diagnosis and therapeutic intervention. However, the availability and efficiencies of existing therapeutic approaches vary depending on the virus. Investigation of the pathologies that are associated with infection by respiratory viruses will be paramount for diagnosis, treatment modalities, and the development of new therapies. Changes in redox homeostasis in infected cells are one of the key events that is linked to infection with respiratory viruses and linked to inflammation and subsequent tissue damage. Our review summarizes current knowledge on changes to redox homeostasis, as induced by the different respiratory viruses.

Indexed as

Oxidation-ReductionOxidative StressAnimalsHumansInflammationMiceNF-E2-Related Factor 2OrthomyxoviridaePneumonia, ViralReactive Oxygen SpeciesRespiratory Syncytial VirusesRespiratory Syncytial Virus InfectionsRespiratory Tract InfectionsRhinovirusNFE2L2 protein, humanNF-E2-Related Factor 2Reactive Oxygen Speciesinflammationinfluenza virusNrf2oxidative stressreactive oxygen speciesrespiratory syncytial virusrhinovirus

Identifiers

PMID30049972
PMCPMC6115776
OpenAlexW2883745760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.