Evidence map›Paper›PMID 30049970›Full record

ArticleGenes2018

TERribly Difficult: Searching for Telomerase RNAs in Saccharomycetes.

Maria Waldl, Bernhard C Thiel, Roman Ochsenreiter, Alexander Holzenleiter, João Victor de Araujo Oliveira, Maria Emília M T Walter, Michael T Wolfinger, Peter F Stadler

Open access · goldAbstract read
In one paragraph

Article in Genes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 4 countries.

Maria WaldlInstitute for Theoretical Chemistry, University of Vienna, Währingerstraße 17, A-1090 Wien, Austria. maria@tbi.univie.ac.at.
Bernhard C ThielInstitute for Theoretical Chemistry, University of Vienna, Währingerstraße 17, A-1090 Wien, Austria. thiel@tbi.univie.ac.at.
Roman OchsenreiterInstitute for Theoretical Chemistry, University of Vienna, Währingerstraße 17, A-1090 Wien, Austria. romanoch@tbi.univie.ac.at.
Alexander HolzenleiterBioInformatics Group, Fakultät CB Hochschule Mittweida, Technikumplatz 17, D-09648 Mittweida, Germany. alexander.holzenleiter@web.de.
João Victor de Araujo OliveiraDepartamento de Ciência da Computação, Instituto de Ciências Exatas, Universidade de Brasília, Campus Universitário⁻Asa Norte, Brasília, DF CEP: 70910-900, Brazil. joaovicers@gmail.com.
Maria Emília M T WalterDepartamento de Ciência da Computação, Instituto de Ciências Exatas, Universidade de Brasília, Campus Universitário⁻Asa Norte, Brasília, DF CEP: 70910-900, Brazil. mariaemilia@unb.br.
Michael T WolfingerInstitute for Theoretical Chemistry, University of Vienna, Währingerstraße 17, A-1090 Wien, Austria. michael.wolfinger@univie.ac.at.ORCID 0000-0003-0925-5205
Peter F StadlerInstitute for Theoretical Chemistry, University of Vienna, Währingerstraße 17, A-1090 Wien, Austria. studla@bioinf.uni-leipzig.de.ORCID 0000-0002-5016-5191
University of Vienna · ATUniversidade de Brasília · BRHochschule Mittweida · DE

Funding

Austrian Science Fund FWF I 2874
6 · The paper itself

Abstract

The telomerase RNA in yeasts is large, usually >1000 nt, and contains functional elements that have been extensively studied experimentally in several disparate species. Nevertheless, they are very difficult to detect by homology-based methods and so far have escaped annotation in the majority of the genomes of Saccharomycotina. This is a consequence of sequences that evolve rapidly at nucleotide level, are subject to large variations in size, and are highly plastic with respect to their secondary structures. Here, we report on a survey that was aimed at closing this gap in RNA annotation. Despite considerable efforts and the combination of a variety of different methods, it was only partially successful. While 27 new telomerase RNAs were identified, we had to restrict our efforts to the subgroup

Indexed as

homology searchnon-coding RNAsecondary structuresyntenytelomerase RNAyeast

Identifiers

PMID30049970
PMCPMC6115765
OpenAlexW2804699938

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.