Evidence map›Paper›PMID 30049932›Full record

ArticleInternational journal of molecular sciences2018

Intracellular Ca

Raúl Lagos-Cabré, Marianne Brenet, Jorge Díaz, Ramón D Pérez, Leonardo A Pérez, Rodrigo Herrera-Molina, Andrew F G Quest, Lisette Leyton

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Calcium Regulation of Connexin Hemichannels.International journal of molecular sciences · 2024
    Review
  5. Article
  6. Article
  7. The Potential Role of Connexins in the Pathogenesis of Atherosclerosis.International journal of molecular sciences · 2023
    Review
  8. Protein kinase B (AKT) upregulation and Thy-1-αJournal of neuroinflammation · 2023
    Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Thy-1/CD90 a Bidirectional and Lateral Signaling Scaffold.Frontiers in cell and developmental biology · 2019
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Raúl Lagos-CabréCellular Communication Laboratory, Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago 838-0453, Chile. rclagos@uc.cl.
Marianne BrenetCellular Communication Laboratory, Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago 838-0453, Chile. mbrenetrivas@gmail.com.
Jorge DíazCellular Communication Laboratory, Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago 838-0453, Chile. jbdiaz1@gmail.com.ORCID 0000-0002-0830-6122
Ramón D PérezCellular Communication Laboratory, Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago 838-0453, Chile. ramonbq@gmail.com.
Leonardo A PérezCellular Communication Laboratory, Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago 838-0453, Chile. leonardo.perez@ug.uchile.cl.
Rodrigo Herrera-MolinaLeibniz Institute for Neurobiology, 39118 Magdeburg, Germany. rherrera@lin-magdeburg.de.
Andrew F G QuestCellular Communication Laboratory, Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago 838-0453, Chile. aquest@med.uchile.cl.
Lisette LeytonCellular Communication Laboratory, Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago 838-0453, Chile. lleyton@med.uchile.cl.ORCID 0000-0001-9690-9638
Advanced Center for Chronic Diseases · CLUniversidad Bernardo O'Higgins · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Under pro-inflammatory conditions, astrocytes become reactive and acquire a migratory phenotype. Our results show that hemichannels formed by connexin 43 (Cx43) play an important role in Thy-1-induced astrocyte migration. The neuronal protein Thy-1 binds to αvβ3 integrin in astrocytes, thereby leading to intricate signaling pathways that include calcium (Ca

Indexed as

Cell MovementAnimalsAstrocytesCalciumCalcium SignalingCell LineCell PolarityCells, CulturedConnexin 43RatsRats, WistarThy-1 AntigensCalciumConnexin 43Thy-1 Antigenscell migrationcell polarizationconnexin 43 hemichannelsgap junctionsinflammationneuronal signalsreactive astrocytes

Identifiers

PMID30049932
PMCPMC6121259
OpenAlexW2883940971

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.