ArticleThe oncologist2019
The Association Between Common Clinical Characteristics and Postoperative Morbidity and Overall Survival in Patients with Glioblastoma.
Article in The oncologist, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Impact of exercise-based prehabilitation on cardiometabolic health in surgical patients with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Pooled it
- Pooled it
- Impact of postoperative blood pressure management on postoperative hemorrhage after resection of intraparenchymal brain tumors.Acta neurochirurgica · 2026Article
- Medical comorbidities prognosticate survival in glioblastoma.BJC reports · 2025Article
- Comparative Clinical-Imaging and Histogenetic Analysis Between Astrocytoma IDH-Mutant Grade 4 and Glioblastoma IDH-Wildtype-Is There Really a Worse One?Diagnostics (Basel, Switzerland) · 2025Article
- The role of postoperative blood pressure management in early postoperative hemorrhage in awake craniotomy glioma patients.Neurosurgical review · 2024Article
- Information-guided Surgery Centered on Intraoperative Magnetic Resonance Imaging Guarantees Surgical Safety with Low Mortality.Neurologia medico-chirurgica · 2024Article
- Diagnosis and management of complications from the treatment of primary central nervous system tumors in adults.Neuro-oncology · 2023Article
- Observational
- Glioblastoma in the Elderly: Review of Molecular and Therapeutic Aspects.Biomedicines · 2022Review
- Prognostic significance of the postoperative prognostic nutritional index in patients with glioblastoma: a retrospective study.BMC cancer · 2021Article
- Prognostic and Predictive Factors in Elderly Patients With Glioblastoma: A Single-Center Retrospective Study.Frontiers in aging neuroscience · 2021Article
- Comorbid Medical Conditions as Predictors of Overall Survival in Glioblastoma Patients.Scientific reports · 2019Article
- Predictors of survival in elderly patients undergoing surgery for glioblastoma.Neuro-oncology advancesArticle
- Real-world mortality and the effect of comorbidities on survival in glioblastoma: A database study using computed phenotypes for rapid, reliable patient identification.Neuro-oncology advancesArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundThe impact of noncancerous factors on the morbidity and mortality of glioblastoma multiforme (GBM) has not been well studied. Using a large surgical cohort, we examined the association between multiple clinical characteristics and postoperative morbidities and survival in patients with GBM. MATERIALS AND
methodsThe study included 404 consecutive GBM patients who underwent initial tumor resection at MD Anderson Cancer Center between January 1, 2010, and December 31, 2014. Data about clinical characteristics, treatments, and postoperative complications were collected. The associations between clinical parameters and postoperative complications and survival were analyzed.
resultsCharlson Comorbidity Index was positively related to a higher incidence of postoperative total (odds ratio [OR] = 1.20;
conclusionShort-term SBp and blood glucose levels and fluctuations are associated with postoperative complications in GBM patients. Their long-term optimization may impact survival of these patients. Future clinical trials are needed to confirm the benefit of optimizing medical comorbidities on GBM patients' outcomes. IMPLICATIONS FOR PRACTICE: Glioblastoma multiforme (GBM) is one of the most feared cancer diagnoses because of its limited survival and treatment. This study revealed significant associations of noncancerous factors on the morbidity and mortality of GBM. The complexity of medical comorbidities, as well as short-term postoperative levels and fluctuations of blood pressure and blood glucose, was associated with postoperative complications, but not overall survival. However, long-term levels of these common clinical parameters were significantly associated with survival. Optimization of medical conditions may be critical for reducing the morbidity and mortality of GBM patients. Future clinical trials are needed to validate the observed associations in an independent cohort.
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