Evidence map›Paper›PMID 30049879›Full record

ArticleScience (New York, N.Y.)2018

Social regulation of insulin signaling and the evolution of eusociality in ants.

Vikram Chandra, Ingrid Fetter-Pruneda, Peter R Oxley, Amelia L Ritger, Sean K McKenzie, Romain Libbrecht, Daniel J C Kronauer

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Genome Evolution in Social Insects.Genome biology and evolution · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Offspring chemical control of adult reproductive transitions in a social insect.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Review
  9. Review
  10. Fraternal cooperation of hierarchical cancer parallels metazoan multicellularity and eusociality.Biological reviews of the Cambridge Philosophical Society · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Static allometries of caste-associated traits vary with genotype but not environment in the clonal raider ant.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. Article
  17. Article
  18. The origin and maintenance of division of labour in an Indian paper wasp.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  19. Review
  20. High Nutritional Conditions Influence Feeding Plasticity in Pristionchus pacificus and Render Worms Non-Predatory.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025
    Article

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Vikram ChandraLaboratory of Social Evolution and Behavior, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. vchandra@rockefeller.edu ifetter@rockefeller.edu dkronauer@rockefeller.edu.ORCID 0000-0002-8020-0664
Ingrid Fetter-PrunedaLaboratory of Social Evolution and Behavior, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. vchandra@rockefeller.edu ifetter@rockefeller.edu dkronauer@rockefeller.edu.ORCID 0000-0002-9122-3159
Peter R OxleyLaboratory of Social Evolution and Behavior, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.ORCID 0000-0001-6170-1220
Amelia L RitgerLaboratory of Social Evolution and Behavior, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.ORCID 0000-0003-2338-6439
Sean K McKenzieLaboratory of Social Evolution and Behavior, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.ORCID 0000-0002-8238-4735
Romain LibbrechtLaboratory of Social Evolution and Behavior, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.ORCID 0000-0003-4397-000X
Daniel J C KronauerLaboratory of Social Evolution and Behavior, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. vchandra@rockefeller.edu ifetter@rockefeller.edu dkronauer@rockefeller.edu.ORCID 0000-0002-4103-7729

Funding

Studying the molecular mechanisms of social life using a novel ant model systemDP2GM105454 · NIGMS · ROCKEFELLER UNIVERSITY · PI KRONAUER, DANIEL · 2012 to 2012
$2.5M
NIGMS NIH HHS DP2 GM105454
6 · The paper itself

Abstract

Queens and workers of eusocial Hymenoptera are considered homologous to the reproductive and brood care phases of an ancestral subsocial life cycle. However, the molecular mechanisms underlying the evolution of reproductive division of labor remain obscure. Using a brain transcriptomics screen, we identified a single gene,

Indexed as

Social BehaviorAnimalsAntsBiological EvolutionBrainGene ExpressionInsulinLarvaReproductionSignal TransductionInsulin

Identifiers

PMID30049879
PMCPMC6178808

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.