ReviewGenetics2018
Developmental Bias and Evolution: A Regulatory Network Perspective.
Review in Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed.
- Synthetic Approaches as Empirical Tools for Testing Evolutionary Theory.Genome biology and evolution · 2026Review
- Color patterns as a model for connecting developmental mechanisms to phenotypic evolution.Nature communications · 2026Review
- Emergence Biases in Molecular Evolution.Genome biology and evolution · 2026Review
- Epistatic impacts of cis- and trans-regulatory mutations on the distribution of mutational effects for gene expression in Saccharomyces cerevisiae.Molecular biology and evolution · 2026Article
- The role of social behaviour in providing resilience to environmental change.The Journal of animal ecology · 2026Article
- Neural crest cell biology shapes lizard skull evolution across evolutionary time scales.Evolution letters · 2026Article
- You Should Look a Gift Ungulate in the Mouth: Using 2D Occlusal Cheek Tooth Morphology to Study the Evolution of Molarization in Ungulates.Integrative organismal biology (Oxford, England) · 2026Article
- The variability of evolvability: Properties of dynamic fitness landscapes determine how phenotypic variability evolves.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Bounding phenotype transition probabilities via conditional complexity.Journal of the Royal Society, Interface · 2025Article
- Developmental lines of least resistance predict standing genetic covariation but do not constrain plasticity or rapid evolution.Proceedings. Biological sciences · 2025Article
- Evolution of developmental bias explains divergent patterns of phenotypic evolution in two nematode clades.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Six million years of vole dental evolution shaped by tooth development.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The Morphological, Behavioral, and Transcriptomic Life Cycle of Anthrobots.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Associative conditioning in gene regulatory network models increases integrative causal emergence.Communications biology · 2025Article
- Congruence between noise and plasticity in protein expression.Scientific reports · 2025Article
- Conserved wing shape variation across biological scales unveils dialectical relationships between micro- and macroevolution.Communications biology · 2025Article
- Harnessing the analog computing power of regulatory networks with the Regulatory Network Machine.iScience · 2025Article
- Spatiotemporal distribution of neural crest cells in the common wall lizard Podarcis muralis.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Article
- A development-centric perspective on pace-of-life syndromes.Evolution letters · 2025Article
- Macroevolution along developmental lines of least resistance in fly wings.Nature ecology & evolution · 2025Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phenotypic variation is generated by the processes of development, with some variants arising more readily than others-a phenomenon known as "developmental bias." Developmental bias and natural selection have often been portrayed as alternative explanations, but this is a false dichotomy: developmental bias can evolve through natural selection, and bias and selection jointly influence phenotypic evolution. Here, we briefly review the evidence for developmental bias and illustrate how it is studied empirically. We describe recent theory on regulatory networks that explains why the influence of genetic and environmental perturbation on phenotypes is typically not uniform, and may even be biased toward adaptive phenotypic variation. We show how bias produced by developmental processes constitutes an evolving property able to impose direction on adaptive evolution and influence patterns of taxonomic and phenotypic diversity. Taking these considerations together, we argue that it is not sufficient to accommodate developmental bias into evolutionary theory merely as a constraint on evolutionary adaptation. The influence of natural selection in shaping developmental bias, and conversely, the influence of developmental bias in shaping subsequent opportunities for adaptation, requires mechanistic models of development to be expanded and incorporated into evolutionary theory. A regulatory network perspective on phenotypic evolution thus helps to integrate the generation of phenotypic variation with natural selection, leaving evolutionary biology better placed to explain how organisms adapt and diversify.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.