Evidence map›Paper›PMID 30049795›Full record

ArticleThe Journal of biological chemistry2018

Structure-function analyses of the bacterial zinc metalloprotease effector protein GtgA uncover key residues required for deactivating NF-κB.

Elliott Jennings, Diego Esposito, Katrin Rittinger, Teresa L M Thurston

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. eLife · 2025
    Article
  6. Article
  7. Comparative genomic profiling of virulence genes in human clinical isolates ofFrontiers in cellular and infection microbiology · 2025
    Article
  8. Article
  9. A novel approach for detectingFrontiers in microbiology · 2024
    Article
  10. Review
  11. Review
  12. Speaking the host language: howMicrobiology (Reading, England) · 2023
    Review
  13. Article
  14. Salmonella enterica serovar Typhi influences inflammation and autophagy in macrophages.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022
    Article
  15. Review
  16. Review
  17. The T3SS Effector Protease NleC Is Active withinPathogens (Basel, Switzerland) · 2021
    Article
  18. Interesting Biochemistries in the Structure and Function of Bacterial Effectors.Frontiers in cellular and infection microbiology · 2021
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Elliott JenningsFrom the Section of Microbiology, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ and.ORCID 0000-0002-3118-2375
Diego Espositothe Molecular Structure of Cell Signalling Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, United Kingdom.
Katrin Rittingerthe Molecular Structure of Cell Signalling Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, United Kingdom.ORCID 0000-0002-7698-4435
Teresa L M ThurstonFrom the Section of Microbiology, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ and t.thurston@imperial.ac.uk.ORCID 0000-0001-6139-3723
Imperial College London · GBThe Francis Crick Institute · GB

Funding

Biotechnology and Biological Sciences Research Council BB/R011834/1Cancer Research UKMedical Research Council MR/P028225/1Wellcome Trust 102410/Z/13/ZRWellcome Trust FC001142
6 · The paper itself

Abstract

The closely related type III secretion system zinc metalloprotease effector proteins GtgA, GogA, and PipA are translocated into host cells during

Indexed as

Amino Acid SequenceCrystallography, X-RayEscherichia coliHeLa CellsHumansImmunity, CellularMetalloproteasesNF-kappa BProtein ConformationSalmonella entericaSalmonella InfectionsSignal TransductionStructure-Activity RelationshipTranscription Factor RelAType III Secretion SystemsZincMetalloproteasesNF-kappa BRELA protein, humanTranscription Factor RelAType III Secretion SystemsZincbacterial effectorsbacterial pathogenesisGtgAmetalloproteaseNF-κBSalmonella entericasubstrate specificitytype III secretion system (T3SS)virulence factor

Identifiers

PMID30049795
PMCPMC6166728
OpenAlexW2883680774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.