Evidence map›Paper›PMID 30049790›Full record

ArticleGenome research2018

GrapeTree: visualization of core genomic relationships among 100,000 bacterial pathogens.

Zhemin Zhou, Nabil-Fareed Alikhan, Martin J Sergeant, Nina Luhmann, Cátia Vaz, Alexandre P Francisco, João André Carriço, Mark Achtman

Abstract read
In one paragraph

Article in Genome research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 664 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
664citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

664 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Persisting predominant clinical CC87Emerging microbes & infections · 2026
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  6. Global genomic landscape of theNew microbes and new infections · 2026
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  14. Extended-Spectrum β-Lactamase-ProducingAnimals : an open access journal from MDPI · 2026
    Article
  15. Surveillance of enteropathogenicJournal of medical microbiology · 2026
    Article
  16. 'Epidemiology ofMicrobial genomics · 2026
    Article
  17. Article
  18. An integrated genomic framework forMicrobial genomics · 2026
    Article
  19. Article
  20. Article

604 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhemin ZhouWarwick Medical School, University of Warwick, Coventry, CV4 7AL, United Kingdom.ORCID 0000-0001-9783-0366
Nabil-Fareed AlikhanWarwick Medical School, University of Warwick, Coventry, CV4 7AL, United Kingdom.ORCID 0000-0002-1243-0767
Martin J SergeantWarwick Medical School, University of Warwick, Coventry, CV4 7AL, United Kingdom.
Nina LuhmannWarwick Medical School, University of Warwick, Coventry, CV4 7AL, United Kingdom.ORCID 0000-0001-8112-7027
Cátia VazInstituto de Engenharia de Sistemas e Computadores: Investigação e Desenvolvimento (INESC-ID), 1000-029 Lisboa, Portugal.ORCID 0000-0001-6074-3074
Alexandre P FranciscoInstituto de Engenharia de Sistemas e Computadores: Investigação e Desenvolvimento (INESC-ID), 1000-029 Lisboa, Portugal.
João André CarriçoInstituto de Microbiologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-004 Lisboa, Portugal.
Mark AchtmanWarwick Medical School, University of Warwick, Coventry, CV4 7AL, United Kingdom.ORCID 0000-0001-6815-0070

Funding

Biotechnology and Biological Sciences Research Council BB/L020319/1Wellcome Trust 202792/Z/16/Z
6 · The paper itself

Abstract

Current methods struggle to reconstruct and visualize the genomic relationships of large numbers of bacterial genomes. GrapeTree facilitates the analyses of large numbers of allelic profiles by a static "GrapeTree Layout" algorithm that supports interactive visualizations of large trees within a web browser window. GrapeTree also implements a novel minimum spanning tree algorithm (MSTree V2) to reconstruct genetic relationships despite high levels of missing data. GrapeTree is a stand-alone package for investigating phylogenetic trees plus associated metadata and is also integrated into EnteroBase to facilitate cutting edge navigation of genomic relationships among bacterial pathogens.

Indexed as

Genome, BacterialPhylogenySoftwareAllelesBacteriaDNA Barcoding, Taxonomic

Identifiers

PMID30049790
PMCPMC6120633

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.