Evidence map›Paper›PMID 30049781›Full record

ArticleGenetics2018

Axonal Mitochondria Modulate Neuropeptide Secretion Through the Hypoxic Stress Response in

Tongtong Zhao, Yingsong Hao, Joshua M Kaplan

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Phylogenetic conservation of the interdependent homeostatic relationship of sleep regulation and redox metabolism.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024
    Review
  4. Article
  5. ClassifyingiScience · 2022
    Article
  6. Review
  7. Article
  8. Selective Advantages of Synapses in Evolution.Frontiers in cell and developmental biology · 2021
    Article
  9. Neuronal Mitophagy: Friend or Foe?Frontiers in cell and developmental biology · 2020
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Tongtong ZhaoDepartment of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114.
Yingsong HaoDepartment of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114.
Joshua M KaplanDepartment of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114 kaplan@molbio.mgh.harvard.edu.
Harvard University · USMassachusetts General Hospital · US

Funding

Regulation of insulin secretion C. elegansR01DK080215 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KAPLAN, JOSHUA M · 2008 to 2016
$3.3M
NIDDK NIH HHS R01 DK080215
6 · The paper itself

Abstract

Neurons are highly dependent on mitochondrial function, and mitochondrial damage has been implicated in many neurological and neurodegenerative diseases. Here we show that axonal mitochondria are necessary for neuropeptide secretion in

Indexed as

AnimalsAxonsCaenorhabditis elegansCaenorhabditis elegans ProteinsHypoxiaMitochondriaNeurodegenerative DiseasesNeuronsNeuropeptidesOxidative PhosphorylationOxidative StressOxygenReactive Oxygen SpeciesReceptors, NeuropeptideTranscription FactorsCaenorhabditis elegans ProteinsHIF-1 protein, C elegansNeuropeptidesOxygenReactive Oxygen SpeciesReceptors, NeuropeptideTranscription FactorsCaenorhabditis eleganshypoxiamitochondrianeuropeptide secretionreactive oxygen species

Identifiers

PMID30049781
PMCPMC6116974
OpenAlexW2884532667

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.