Trial reportArchives of disease in childhood. Fetal and neonatal edition2019
Nebulised surfactant to reduce severity of respiratory distress: a blinded, parallel, randomised controlled trial.
Trial report in Archives of disease in childhood. Fetal and neonatal edition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04315636 (Surfactant Nebulization for the Early Aeration of the Preterm Lung), which is not on this map. Cited by 47 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Surfactant Nebulization for the Early Aeration of the Preterm Lung: a Single Blinded, Parallel, Randomized Controlled Trial
Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 121 citations in OpenAlex.
- Comparative efficacy and safety of pulmonary surfactant delivery strategies in neonatal RDS: a network meta-analysis.BMC pulmonary medicine · 2024Pooled it
- Pooled it
- European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2019 Update.Neonatology · 2019Guideline
- Vibrating mesh nebulizers vs. less invasive surfactant administration in the treatment of preterm respiratory distress syndrome: a multicenter, open-label, exploratory, randomized clinical trial.European journal of medical research · 2025Trial
- Response to aerosolized calfactant in infants with respiratory distress syndrome; a post-hoc analysis of AERO-02 trial.Journal of perinatology : official journal of the California Perinatal Association · 2023Trial
- Nasal high-flow therapy to Optimise Stability during Intubation: the NOSI pilot trial.Archives of disease in childhood. Fetal and neonatal edition · 2023Trial
- Non-Invasive Surfactant Administration in Preterm Infants.Children (Basel, Switzerland) · 2026Review
- Prophylactic surfactant therapy in the era of less invasive surfactant delivery.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Preclinical Testing of a New Dry Powder Aerosol Synthetic Lung Surfactant Formulation and Device Combination for the Treatment of Neonatal Respiratory Distress Syndrome.Journal of aerosol medicine and pulmonary drug delivery · 2025Article
- Development of a New Dry Powder Aerosol Synthetic Lung Surfactant Product for Neonatal Respiratory Distress Syndrome (RDS) - Part II: In vivo Efficacy Testing in a Rabbit Surfactant Washout Model.Pharmaceutical research · 2024Article
- Development of a New Dry Powder Aerosol Synthetic Lung Surfactant Product for Neonatal Respiratory Distress Syndrome (RDS) - Part I: In Vitro Testing and Characterization.Pharmaceutical research · 2024Article
- Less invasive surfactant administration methods: Who, what and how.Journal of perinatology : official journal of the California Perinatal Association · 2024Review
- Prophylactic Oropharyngeal Surfactant for Preterm Newborns at Birth: A Randomized Clinical Trial.JAMA pediatrics · 2024Article
- Nebuliser therapy in critical care: The past, present and future.Journal of the Intensive Care Society · 2024Review
- Less Invasive Surfactant Administration: A Viewpoint.American journal of perinatology · 2024Review
- Surfactant therapy using vibrating-mesh nebulizers in adults with COVID-19-induced ARDS: A case series.SAGE open medical case reports · 2024Article
- A multicentre neonatal interventional randomised controlled trial of nebulized surfactant for preterm infants with respiratory distress: Neo-INSPIRe trial protocol.BMC pediatrics · 2023Article
- Pulmonary Surfactant in Adult ARDS: Current Perspectives and Future Directions.Diagnostics (Basel, Switzerland) · 2023Review
- Clinical decision thresholds for surfactant administration in preterm infants: a systematic review and network meta-analysis.EClinicalMedicine · 2023Article
- Respiratory Management of the Preterm Infant: Supporting Evidence-Based Practice at the Bedside.Children (Basel, Switzerland) · 2023Review
Corrections and comments
- Commented on by
- Erratum issuedCorrection:2020
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate if nebulised surfactant reduces intubation requirement in preterm infants with respiratory distress treated with nasal continuous positive airway pressure (nCPAP).
designDouble blind, parallel, stratified, randomised control trial.
settingSole tertiary neonatal unit in West Australia. PATIENTS: Preterm infants (29
interventionsInfants were randomised within strata (29
main outcome measuresThe primary outcomes were requirement for intubation and duration of mechanical ventilation at 72 hours. Data analysis followed the intention-to-treat principle.
results360 of 606 assessed infants were eligible; 64 of 360 infants were enrolled and randomised (n=32/group). Surfactant nebulisation reduced the requirement for intubation within 72 hours: 11 of 32 infants were intubated after continuous positive airway pressure (CPAP) and nebulised surfactant compared with 22 of 32 infants receiving CPAP alone (relative risk (95% CI)=0.526 (0.292 to 0.950)). The reduced requirement for intubation was limited to the 32
conclusionsEarly postnatal nebulised surfactant may reduce the need for intubation in the first 3 days of life compared with nCPAP alone in infants born at 29 TRIAL REGISTRATION NUMBER: ACTRN12610000857000.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.