Evidence map›Paper›PMID 30049723›Full record

ArticleAJNR. American journal of neuroradiology2018

Hybrid 3D/2D Convolutional Neural Network for Hemorrhage Evaluation on Head CT.

P D Chang, E Kuoy, J Grinband, B D Weinberg, M Thompson, R Homo, J Chen, H Abcede, M Shafie, L Sugrue and 5 more

Open access · hybridAbstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 4 pooled it
20.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 4 syntheses or guidelines pooled it, 274 citations in OpenAlex.

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  5. [Hematoma Segmentation of Spontaneous Intracerebral Hemorrhage Based on Watershed and Region-Growing Algorithm].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022
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38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 1 country.

P D ChangFrom the Departments of Radiology (P.D.C., E.K., M.T., R.H., M.-Y.S., D.C.).ORCID 0000-0002-2675-9483
E KuoyFrom the Departments of Radiology (P.D.C., E.K., M.T., R.H., M.-Y.S., D.C.).ORCID 0000-0003-4721-1254
J GrinbandDepartment of Radiology (J.G.), Columbia University, New York, New York.ORCID 0000-0001-7658-6755
B D WeinbergDepartment of Radiology (B.D.W.), Emory University School of Medicine, Atlanta, Georgia.ORCID 0000-0002-7992-1747
M ThompsonFrom the Departments of Radiology (P.D.C., E.K., M.T., R.H., M.-Y.S., D.C.).ORCID 0000-0003-1782-3399
R HomoFrom the Departments of Radiology (P.D.C., E.K., M.T., R.H., M.-Y.S., D.C.).ORCID 0000-0002-8671-4893
J ChenNeurosurgery (J.C.).ORCID 0000-0003-0624-6864
H AbcedeNeurology (H.A., M.S., W.Y.), University of California Irvine.ORCID 0000-0002-9691-5066
M ShafieNeurology (H.A., M.S., W.Y.), University of California Irvine.ORCID 0000-0002-4053-2322
L SugrueDepartments of Radiology (P.D.C., L.S., C.H.), University of California, San Francisco, California.ORCID 0000-0001-7315-4519
C G FilippiDepartment of Radiology (C.G.F.), North Shore University Hospital, Long Island, New York.ORCID 0000-0002-4565-2614
M-Y SuFrom the Departments of Radiology (P.D.C., E.K., M.T., R.H., M.-Y.S., D.C.).ORCID 0000-0002-3069-0271
W YuNeurology (H.A., M.S., W.Y.), University of California Irvine.ORCID 0000-0003-1664-3580
C HessDepartments of Radiology (P.D.C., L.S., C.H.), University of California, San Francisco, California.ORCID 0000-0002-5132-5302
D ChowFrom the Departments of Radiology (P.D.C., E.K., M.T., R.H., M.-Y.S., D.C.) chowd3@uci.edu.ORCID 0000-0002-2359-7394
Hesco (United States) · USUniversity of California, Irvine · USUniversity of California, San Francisco · USC3J Therapeutics (United States) · USColumbia University · USEmory University · USNeurology, Inc · USNorth Shore University Hospital · US

Funding

Biomedical Imaging for Clinician ScientistsT32EB001631 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI THOMAS M LINK · 2005 to 2026
$5.6M
NIBIB NIH HHS T32 EB001631
6 · The paper itself

Abstract

background and purposeConvolutional neural networks are a powerful technology for image recognition. This study evaluates a convolutional neural network optimized for the detection and quantification of intraparenchymal, epidural/subdural, and subarachnoid hemorrhages on noncontrast CT. MATERIALS AND

methodsThis study was performed in 2 phases. First, a training cohort of all NCCTs acquired at a single institution between January 1, 2017, and July 31, 2017, was used to develop and cross-validate a custom hybrid 3D/2D mask ROI-based convolutional neural network architecture for hemorrhage evaluation. Second, the trained network was applied prospectively to all NCCTs ordered from the emergency department between February 1, 2018, and February 28, 2018, in an automated inference pipeline. Hemorrhage-detection accuracy, area under the curve, sensitivity, specificity, positive predictive value, and negative predictive value were assessed for full and balanced datasets and were further stratified by hemorrhage type and size. Quantification was assessed by the Dice score coefficient and the Pearson correlation.

resultsA 10,159-examination training cohort (512,598 images; 901/8.1% hemorrhages) and an 862-examination test cohort (23,668 images; 82/12% hemorrhages) were used in this study. Accuracy, area under the curve, sensitivity, specificity, positive predictive value, and negative-predictive value for hemorrhage detection were 0.975, 0.983, 0.971, 0.975, 0.793, and 0.997 on training cohort cross-validation and 0.970, 0.981, 0.951, 0.973, 0.829, and 0.993 for the prospective test set. Dice scores for intraparenchymal hemorrhage, epidural/subdural hemorrhage, and SAH were 0.931, 0.863, and 0.772, respectively.

conclusionsA customized deep learning tool is accurate in the detection and quantification of hemorrhage on NCCT. Demonstrated high performance on prospective NCCTs ordered from the emergency department suggests the clinical viability of the proposed deep learning tool.

Indexed as

Deep LearningHumansImaging, Three-DimensionalIntracranial HemorrhagesNeuroimagingProspective StudiesSensitivity and SpecificityTomography, X-Ray Computed

Identifiers

PMID30049723
PMCPMC6128745
OpenAlexW2883545264

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.