Evidence map›Paper›PMID 30049711›Full record

ArticleThe EMBO journal2018

Neuregulin 3 promotes excitatory synapse formation on hippocampal interneurons.

Thomas Müller, Stephanie Braud, René Jüttner, Birgit C Voigt, Katharina Paulick, Maria E Sheean, Constantin Klisch, Dilansu Gueneykaya, Fritz G Rathjen, Jörg Rp Geiger and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in The EMBO journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
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  10. Comprehensive characterization of the RNA editing landscape in the human aging brains with Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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  20. Parvalbumin interneuron deficits in schizophrenia.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Thomas MüllerDevelopmental Biology/Signal Transduction Group, Max-Delbrueck-Centrum in the Helmholtz Association, Berlin, Germany.ORCID 0000-0001-8096-1853
Stephanie BraudInstitute of Neurophysiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
René JüttnerDevelopmental Neurobiology Group, Max-Delbrueck-Centrum in the Helmholtz Association, Berlin, Germany.ORCID 0000-0003-3565-0698
Birgit C VoigtNeural Circuits and Behaviour Group, Max-Delbrueck-Centrum in the Helmholtz Association, Berlin, Germany.ORCID 0000-0002-2520-0178
Katharina PaulickDevelopmental Biology/Signal Transduction Group, Max-Delbrueck-Centrum in the Helmholtz Association, Berlin, Germany.ORCID 0000-0002-8079-5944
Maria E SheeanDevelopmental Biology/Signal Transduction Group, Max-Delbrueck-Centrum in the Helmholtz Association, Berlin, Germany.ORCID 0000-0003-3055-0495
Constantin KlischInstitute of Neurophysiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Dilansu GueneykayaCellular Neuroscience Group, Max-Delbrueck-Centrum in the Helmholtz Association, Berlin, Germany.
Fritz G RathjenDevelopmental Neurobiology Group, Max-Delbrueck-Centrum in the Helmholtz Association, Berlin, Germany.ORCID 0000-0001-5351-613X
Jörg Rp GeigerInstitute of Neurophysiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
James Fa PouletNeural Circuits and Behaviour Group, Max-Delbrueck-Centrum in the Helmholtz Association, Berlin, Germany.ORCID 0000-0003-0296-5415
Carmen BirchmeierDevelopmental Biology/Signal Transduction Group, Max-Delbrueck-Centrum in the Helmholtz Association, Berlin, Germany cbirch@mdc-berlin.de.ORCID 0000-0002-2041-8872
Helmholtz Association of German Research Centres · DECharité - Universitätsmedizin Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hippocampal GABAergic interneurons are crucial for cortical network function and have been implicated in psychiatric disorders. We show here that Neuregulin 3 (Nrg3), a relatively little investigated low-affinity ligand, is a functionally dominant interaction partner of ErbB4 in parvalbumin-positive (PV) interneurons. Nrg3 and ErbB4 are located pre- and postsynaptically, respectively, in excitatory synapses on PV interneurons

Indexed as

Neuronal PlasticityAnimalsHippocampusInterneuronsIntracellular Signaling Peptides and ProteinsMiceMice, TransgenicNerve NetNeuregulinsReceptor, ErbB-4SynapsesErbb4 protein, mouseIntracellular Signaling Peptides and ProteinsNeuregulinsNrg3 protein, mouseReceptor, ErbB-4ErbB4GABAergic interneuronshippocampussynaptogenesis

Identifiers

PMID30049711
PMCPMC6120667
OpenAlexW2883892282

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.