Evidence map›Paper›PMID 30049567›Full record

ArticleJournal of cataract and refractive surgery2018

Quantifying the effects of hydration on corneal stiffness with noncontact optical coherence elastography.

Manmohan Singh, Zhaolong Han, Jiasong Li, Srilatha Vantipalli, Salavat R Aglyamov, Michael D Twa, Kirill V Larin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cataract and refractive surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Effects of caffeine intake on the biomechanical properties of the cornea: a placebo-controlled, double-blind, crossover pilot study in low caffeine consumers.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020
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  10. Hyaluronan Modulates the Biomechanical Properties of the Cornea.Investigative ophthalmology & visual science · 2022
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  15. Biomedical optics express · 2022
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  18. Wave-based optical coherence elastography: The 10-year perspective.Progress in biomedical engineering (Bristol, England) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Manmohan SinghFrom Biomedical Engineering (Singh, Li, Larin) and the College of Optometry (Vantipalli), Mechanical Engineering (Aglyamov), University of Houston, and Molecular Physiology and Biophysics (Larin), Baylor College of Medicine, Houston, Texas, and the School of Optometry (Twa) and Biomedical Engineering (Twa), University of Alabama at Birmingham, Birmingham, Alabama, USA; The School of Naval Architecture (Han), Ocean and Civil Engineering, Shanghai Jiao Tong University, Shanghai, China; Interdisciplinary Laboratory of Biophotonics (Larin), Tomsk State University, Tomsk, Russia.
Zhaolong HanFrom Biomedical Engineering (Singh, Li, Larin) and the College of Optometry (Vantipalli), Mechanical Engineering (Aglyamov), University of Houston, and Molecular Physiology and Biophysics (Larin), Baylor College of Medicine, Houston, Texas, and the School of Optometry (Twa) and Biomedical Engineering (Twa), University of Alabama at Birmingham, Birmingham, Alabama, USA; The School of Naval Architecture (Han), Ocean and Civil Engineering, Shanghai Jiao Tong University, Shanghai, China; Interdisciplinary Laboratory of Biophotonics (Larin), Tomsk State University, Tomsk, Russia.
Jiasong LiFrom Biomedical Engineering (Singh, Li, Larin) and the College of Optometry (Vantipalli), Mechanical Engineering (Aglyamov), University of Houston, and Molecular Physiology and Biophysics (Larin), Baylor College of Medicine, Houston, Texas, and the School of Optometry (Twa) and Biomedical Engineering (Twa), University of Alabama at Birmingham, Birmingham, Alabama, USA; The School of Naval Architecture (Han), Ocean and Civil Engineering, Shanghai Jiao Tong University, Shanghai, China; Interdisciplinary Laboratory of Biophotonics (Larin), Tomsk State University, Tomsk, Russia.
Srilatha VantipalliFrom Biomedical Engineering (Singh, Li, Larin) and the College of Optometry (Vantipalli), Mechanical Engineering (Aglyamov), University of Houston, and Molecular Physiology and Biophysics (Larin), Baylor College of Medicine, Houston, Texas, and the School of Optometry (Twa) and Biomedical Engineering (Twa), University of Alabama at Birmingham, Birmingham, Alabama, USA; The School of Naval Architecture (Han), Ocean and Civil Engineering, Shanghai Jiao Tong University, Shanghai, China; Interdisciplinary Laboratory of Biophotonics (Larin), Tomsk State University, Tomsk, Russia.
Salavat R AglyamovFrom Biomedical Engineering (Singh, Li, Larin) and the College of Optometry (Vantipalli), Mechanical Engineering (Aglyamov), University of Houston, and Molecular Physiology and Biophysics (Larin), Baylor College of Medicine, Houston, Texas, and the School of Optometry (Twa) and Biomedical Engineering (Twa), University of Alabama at Birmingham, Birmingham, Alabama, USA; The School of Naval Architecture (Han), Ocean and Civil Engineering, Shanghai Jiao Tong University, Shanghai, China; Interdisciplinary Laboratory of Biophotonics (Larin), Tomsk State University, Tomsk, Russia.
Michael D TwaFrom Biomedical Engineering (Singh, Li, Larin) and the College of Optometry (Vantipalli), Mechanical Engineering (Aglyamov), University of Houston, and Molecular Physiology and Biophysics (Larin), Baylor College of Medicine, Houston, Texas, and the School of Optometry (Twa) and Biomedical Engineering (Twa), University of Alabama at Birmingham, Birmingham, Alabama, USA; The School of Naval Architecture (Han), Ocean and Civil Engineering, Shanghai Jiao Tong University, Shanghai, China; Interdisciplinary Laboratory of Biophotonics (Larin), Tomsk State University, Tomsk, Russia.
Kirill V LarinFrom Biomedical Engineering (Singh, Li, Larin) and the College of Optometry (Vantipalli), Mechanical Engineering (Aglyamov), University of Houston, and Molecular Physiology and Biophysics (Larin), Baylor College of Medicine, Houston, Texas, and the School of Optometry (Twa) and Biomedical Engineering (Twa), University of Alabama at Birmingham, Birmingham, Alabama, USA; The School of Naval Architecture (Han), Ocean and Civil Engineering, Shanghai Jiao Tong University, Shanghai, China; Interdisciplinary Laboratory of Biophotonics (Larin), Tomsk State University, Tomsk, Russia. Electronic address: klarin@uh.edu.

Funding

Research Programming ModuleP30EY007551 · NEI · UNIVERSITY OF HOUSTON · PI LAURA J. FRISHMAN · 1988 to 2026
$16.4M
Optical Coherence Elastography of the CorneaR01EY022362 · NEI · UNIVERSITY OF HOUSTON · PI Salavat R Aglyamov, Kirill V Larin · 2012 to 2026
$6.7M
NEI NIH HHS P30 EY007551NEI NIH HHS R01 EY022362
6 · The paper itself

Abstract

purposeTo quantify the effects of the hydration state on the Young's modulus of the cornea.

settingBiomedical Optics Laboratory, University of Houston, Houston, Texas, USA.

designExperimental study.

methodsNoncontact, dynamic optical coherence elastography (OCE) measurements were taken of in situ rabbit corneas in the whole eye-globe configuration (n = 10) and at an artificially controlled intraocular pressure of 15 mm Hg. Baseline OCE measurements were taken by topically hydrating the corneas with saline for 1 hour. The corneas were then dehydrated topically with a 20% dextran solution for another hour, and the OCE measurements were repeated. A finite element method was used to quantify the Young's modulus of the corneas based on the OCE measurements.

resultsThe thickness of the corneas shrank considerably after topical addition of the 20% dextran solution (∼680 μm to ∼370 μm), and the OCE-measured elastic-wave speed correspondingly decreased (∼3.2 m/s to ∼2.6 m/s). The finite element method results showed an increase in Young's modulus (500 kPa to 800 kPa) resulting from dehydration and subsequent thinning.

conclusionYoung's modulus increased significantly as the corneas dehydrated and thinned, showing that corneal geometry and hydration state are critical factors for accurately quantifying corneal biomechanical properties.

Indexed as

CorneaAnimalsDiagnostic Techniques, OphthalmologicalElasticity Imaging TechniquesElastic ModulusRabbitsSaline SolutionTomography, Optical CoherenceSaline Solution

Identifiers

PMID30049567
PMCPMC6097919

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.