Evidence map›Paper›PMID 30049425›Full record

ArticlePediatric neurology2018

Home-Based, Therapist-Assisted, Therapy for Young Children With Primary Complex Motor Stereotypies.

Harvey S Singer, Shreenath Rajendran, H Richard Waranch, E Mark Mahone

Abstract read
In one paragraph

Article in Pediatric neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Cognitive outcomes of the at-home brain balance program.Frontiers in child and adolescent psychiatry · 2024
    Article
  3. Article
  4. Article
  5. Aberrant prefrontal cortical-striatal functional connectivity in children with primary complex motor stereotypies.Cortex; a journal devoted to the study of the nervous system and behavior · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Harvey S SingerJohns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address: hsinger@jhmi.edu.
Shreenath RajendranJohns Hopkins University School of Medicine, Baltimore, Maryland.
H Richard WaranchJohns Hopkins University School of Medicine, Baltimore, Maryland.
E Mark MahoneJohns Hopkins University School of Medicine, Baltimore, Maryland; Kennedy Krieger Institute, Baltimore, Maryland.
Johns Hopkins University · USKennedy Krieger Institute · US

Funding

Translational Neuroscience CoreU54HD079123 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI FATEMI, S. ALI, SCHLAGGAR, BRADLEY L · 2014 to 2019
$7.9M
Institute for Clinical and Translational ResearchUL1TR000424 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2012 to 2012
$6.0M
NCATS NIH HHS UL1 TR000424NICHD NIH HHS U54 HD079123
6 · The paper itself

Abstract

backgroundComplex motor stereotypies (CMS) typically begin before age three years and include rhythmic, repetitive, fixed movements that last for seconds to minutes and can be interrupted with distraction.

objectiveWe evaluated the effectiveness of a home-based, parent-provided therapy accompanied by scheduled telephone calls with a therapist, in five- to seven-year old children with primary CMS.

methodsEligible families received an instructional digital versatile disk (DVD) written instructions, and scheduled telephone contacts with a therapist at baseline (DVD receipt), one, three, and eight weeks later. At each call, parents completed outcome measures and received feedback. Outcome scales Stereotypy Severity Scale (SSS) Motor and Impairment scales and a Stereotypy Linear Analogue Scale (SLAS) were also completed via the Iinternet (REDCap)-at screening, one and two months post-baseline call. At study conclusion, participants were divided into an intent-to-treat (ITT; had at least one call) or a lost-to-follow-up (LTF) group.

resultsThirty-eight children (mean =  6 years ± 11 months) were enrolled. The LTF group (n = 14) had significantly higher scores than the ITT (n = 24) group on all attention-deficit/hyperactivity disorder ratings (P < 0.01), but not stereotypy severity. Primary outcome scores, acquired by telephone and REDCap, showed a significant reduction in SSS Motor and Impairment scores between the initial and the last completed evaluation (P ≤ 0.001). Calculated change ratios were SSS Motor -0.23/-0.30 (cal/REDCap); SSS Impairment -0.31/-0.32; and SLAS -0.54 (REDCap). Clinical improvement was further supported by results from a parent improvement scale and end of study questionnaires.

conclusionsHome-based, parent-administered behavioral therapy supplemented by telephone contact with a therapist is effective in reducing complex motor stereotypies in children.

Indexed as

Patient Education as TopicTelemedicineBehavior TherapyChildChild, PreschoolFeedbackFemaleFollow-Up StudiesHumansMaleMotion PicturesParentsSeverity of Illness IndexStereotypic Movement DisorderTreatment OutcomeBehavioral therapyHome-based therapyMotor stereotypiesMovement disorderStereotypy Severity Scale

Identifiers

PMID30049425
PMCPMC6195441
OpenAlexW2803825546

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.