Evidence map›Paper›PMID 30048919›Full record

ReviewMultiple sclerosis and related disorders2018

MOG antibody disease: A review of MOG antibody seropositive neuromyelitis optica spectrum disorder.

Ram Narayan, Alexandra Simpson, Katelyn Fritsche, Sara Salama, Santiago Pardo, Maureen Mealy, Friedemann Paul, Michael Levy

Abstract readReview
PubMed Publisher
In one paragraph

Review in Multiple sclerosis and related disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 1 pooled it
20.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 1 synthesis or guideline pooled it, 186 citations in OpenAlex.

  1. Pooled it
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  12. Case of MOG-IgG-associated disease with ankylosing spondylitis: A rare coexistence.Turkish journal of physical medicine and rehabilitation · 2023
    Article
  13. Article
  14. Establishment of a comprehensive diagnostic model for neuromyelitis optica spectrum disorders based on the analysis of laboratory indicators and clinical data.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Article
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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Ram NarayanDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA; Department of Neurology, University of Texas Southwestern, Dallas, TX, USA.
Alexandra SimpsonDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Katelyn FritscheDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Sara SalamaDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA; Department of Neurology, University of Alexandria, Alexandria, Egypt.
Santiago PardoDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Maureen MealyDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Friedemann PaulCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, NeuroCure Clinical Research Center, Berlin, Germany; Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
Michael LevyDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA. Electronic address: mlevy@jhmi.edu.
Johns Hopkins University · USMax Delbrück Center · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MOG antibody disease is an autoimmune disease of the central nervous system associated with a serological antibody against MOG, myelin oligodendrocyte glycoprotein. MOG is a glycoprotein expressed on the outer membrane of myelin and solely found within the central nervous system, including in the brain, optic nerves and spinal cord. Clinically, the disease resembles neuromyelitis optica spectrum disorders in the predilection for relapses of optic neuritis and transverse myelitis. In addition, acute disseminated encephalomyelitis (ADEM) is a well-recognized phenotype of MOG antibody disease in children. In recent studies around the world where MOG testing is available, up to 42% of NMOSD patients who test seronegative for the AQP4 antibody test positive for MOG antibodies. MOG antibody disease has thus recently emerged as a distinct entity carved out of the patient population diagnosed with NMOSD. In this review, we examine the history of the MOG antibody and its relevance to demyelinating disease, as well as compare the clinical, radiographic and serological profiles of patients with MOG antibody with patients with AQP4 antibody.

Indexed as

AnimalsAutoantibodiesHumansMyelin-Oligodendrocyte GlycoproteinNeuromyelitis OpticaAutoantibodiesMyelin-Oligodendrocyte Glycoprotein

Identifiers

PMID30048919
OpenAlexW2884537445

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.