ArticleNeurobiology of aging2018
The association between brain volume, cortical brain infarcts, and physical frailty.
Article in Neurobiology of aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
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Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Neuroimaging Findings in Nondemented Frail Individuals: A Systematic Review.Journal of cachexia, sarcopenia and muscle · 2025Pooled it
- Psychological and Social Factors Associated with Coexisting Frailty and Cognitive Impairment: A Systematic Review.Research on agingPooled it
- Synthetic MRI Neuroimaging Correlates of Frailty: Correlations Between Frailty Scales and Brain Structural Integrity.Aging medicine (Milton (N.S.W)) · 2026Article
- Frailty Exacerbates Disability in Progressive Multiple Sclerosis.Annals of clinical and translational neurology · 2026Article
- Article
- Association between cerebrospinal fluid volume and frailty in community-dwelling older adults: a cross-sectional study.Fluids and barriers of the CNS · 2026Article
- Oral frailty trajectories and influencing factors in older adults with stroke: a longitudinal study.BMC nursing · 2025Article
- Frailty subtypes and white matter alterations in older adults without dementia.Psychiatry and clinical neurosciences · 2025Article
- Associations of neurodegenerative and cerebrovascular neuropathology with frailty in a diverse sample.Acta neuropathologica communications · 2025Article
- Single cell RNA sequencing analysis of mice hindlimb muscles identifies transcriptional heterogeneity in aging and physical frailty.Scientific reports · 2025Article
- A secondary analysis of cortical atrophy and plasma amyloid β patterns in older patients with cognitive frailty undergoing elective surgery.BMC geriatrics · 2025Article
- Shared genetic architecture and causal relationship between frailty and schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- Frailty links the heterogeneity of tinnitus disorder and response to interventions in older patients.Frontiers in neurology · 2025Review
- Association between surgical admissions, cognition, and neurodegeneration in older people: a population-based study from the UK Biobank.The lancet. Healthy longevity · 2024Article
- Cerebrospinal fluid proteomic profile of frailty: Results from the PROLIPHYC cohort.Aging cell · 2024Article
- Association between physical frailty and cortical structure in middle-aged and elderly people: a Mendelian randomization study.Frontiers in aging neuroscience · 2024Article
- Neuroimaging features of depression-frailty phenotype in older adults: a pilot study.International psychogeriatrics · 2023Article
- Correlation between burst suppression and postoperative delirium in elderly patients: a prospective study.Aging clinical and experimental research · 2023Article
- Temporal lobe atrophy as a potential predictor of functional outcome in older adults with acute ischemic stroke.Acta neurologica Belgica · 2023Article
- A genome-wide association study of frailty identifies significant genetic correlation with neuropsychiatric, cardiovascular, and inflammation pathways.GeroScience · 2023Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
Physical frailty is an age-associated syndrome of decreased reserve leading to vulnerability to physiological stressors and associated with negative outcomes. The underlying structural brain abnormalities of physical frailty are unclear. We investigated the association between brain volume, cortical brain infarcts, and physical frailty. In this multicenter study, 214 nondemented participants were classified as frail (n = 32), prefrail (n = 107), or nonfrail (n = 75) based on the Fried frailty phenotype. The associations between frailty and brain volumes and cortical brain infarcts were investigated by linear or logistic regression analyses. Participants in the frail group showed a lower total brain volume (-19.67 mL [95% confidence interval -37.84 to -1.50]) and lower gray matter volume (-12.19 mL [95% confidence interval -23.84 to -0.54]) compared to nonfrail participants. Frailty was associated with cortical brain infarcts [frail 16% [n = 5], prefrail 11% [n = 12], and nonfrail 3% [n = 2]). Reduced total brain volume and gray matter volume and increased cortical brain infarcts seem therefore to be part of the structural substrate of the physical frailty phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.