Evidence map›Paper›PMID 30048816›Full record

ArticleNanomedicine : nanotechnology, biology, and medicine2018

Multi-parameter MRI to investigate vasculature modulation and photo-thermal ablation combination therapy against cancer.

Yesen Li, Jing Ye, Shiyi Zhou, Ruiliang Bai, Guifeng Fu, Weizhong Zhang, Isabel X Zhang, Gang Liu, Fan Zhang, Jin Xie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomedicine : nanotechnology, biology, and medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yesen LiDepartment of Nuclear Medicine and Minnan PET center, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
Jing YeState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, Fujian, China.
Shiyi ZhouDepartment of Chemistry, University of Georgia, Athens, GA, USA.
Ruiliang BaiInterdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, Key Laboratory of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, Zhejiang, China.
Guifeng FuState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, Fujian, China.
Weizhong ZhangDepartment of Chemistry, University of Georgia, Athens, GA, USA.
Isabel X ZhangDepartment of Chemistry, University of Georgia, Athens, GA, USA.
Gang LiuState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, Fujian, China.
Fan ZhangState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, Fujian, China. Electronic address: sailfmri@hotmail.com.
Jin XieDepartment of Chemistry, University of Georgia, Athens, GA, USA; Bio-Imaging Research Center, University of Georgia, Athens, GA, USA. Electronic address: jin.xie@uga.edu.

Funding

Combined Nanoparticle and Neural Stem Cell Therapies in a Pig Model of StrokeR01NS093314 · NINDS · UNIVERSITY OF GEORGIA · PI WEST, FRANKLIN D · 2015 to 2019
$2.4M
Nanoscintillator-based X-ray sensitizers to enable efficient NSCLC treatment with X-ray irradiationR01EB022596 · NIBIB · UNIVERSITY OF GEORGIA · PI XIE, JIN · 2017 to 2020
$1.9M
NIBIB NIH HHS R01 EB022596NIH HHS R01EB022596NIH HHS R01NS093314NINDS NIH HHS R01 NS093314
6 · The paper itself

Abstract

Nanotransducer-mediated photothermal therapy (PTT) has emerged as an attractive therapy modality against cancer, but its efficacy is often limited by the amount of nanoparticles delivered to tumors. Previous studies showed a vasculature modulation treatment, which dilates or prunes tumor blood vessels, may enhance tumor uptake of nanoparticles. However, exploiting these approaches for improved PTT has seldom been studied. In this study, we investigated the impact of mild hyperthermia or anti-angiogenesis therapy on PTT. Briefly, we gave tumor-bearing balb/c mice low doses of sunitinib or submerged tumors in a 42 °C water bath. Next, we injected PEGylated reduced graphene oxide (RGO-PEG) and irradiated the tumors to induce PTT. We then followed up the treatment with multi-parameter MRI. Contrary to expectation, both vessel modulation strategies led to diminished PTT efficacy. Our results show that vessel modulation does not warrant improved PTT, and should be carefully gauged when used in combination with PTT.

Indexed as

Hyperthermia, InducedPhototherapyAngiogenesis InhibitorsAnimalsApoptosisBreast NeoplasmsCell ProliferationCombined Modality TherapyFemaleGraphiteHumansMagnetic Resonance ImagingMiceMice, Inbred BALB CMice, NudeNanoparticlesAngiogenesis InhibitorsGraphiteSunitinibHyperthermiaMagnetic resonance imagingNanoparticlesPhotothermal therapyReduced graphene oxide

Identifiers

PMID30048816
PMCPMC6398934

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.