ArticleNanomedicine : nanotechnology, biology, and medicine2018
In vivo biodistribution and toxicology studies of cadmium-free indium-based quantum dot nanoparticles in a rat model.
Article in Nanomedicine : nanotechnology, biology, and medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
27 citing papers in PubMed, 70 citations in OpenAlex.
- Indium phosphide quantum dots: advanced synthesis, surface engineering, and biomedical applications in imaging, sensing, and therapy.RSC advances · 2026Review
- Multifunctional quantum dot-decorated drug-loaded magnetite nanosystem for dual optical-magnetic resonance imaging and drug delivery.RSC advances · 2025Article
- Amino acid assisted synthesis of CDs: a novel paradigm in plant tissue culture media for enhanced cellular effects and biotechnological advancements.RSC advances · 2025Article
- PEGylation of indium phosphide quantum dots prevents quantum dot mediated platelet activation.Journal of materials chemistry. B · 2025Article
- Molecular mechanism of nanomaterials induced liver injury: A review.World journal of hepatology · 2024Review
- Review
- Interactions between Quantum Dots and G-Actin.International journal of molecular sciences · 2023Article
- Current Advances in the Biomedical Applications of Quantum Dots: Promises and Challenges.International journal of molecular sciences · 2023Review
- Potential Development of N-Doped Carbon Dots and Metal-Oxide Carbon Dot Composites for Chemical and Biosensing.Nanomaterials (Basel, Switzerland) · 2022Review
- Quantum Dots and Their Interaction with Biological Systems.International journal of molecular sciences · 2022Review
- In Vivo Biodistribution, Clearance, and Biocompatibility of Multiple Carbon Dots Containing Nanoparticles for Biomedical Application.Pharmaceutics · 2021Article
- Safety Evaluation of Nanotechnology Products.Pharmaceutics · 2021Review
- Population pharmacokinetic modelling of indium-based quantum dot nanoparticles: preclinical in vivo studies.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2021Review
- Evaluation of the Dermal Toxicity of InZnP Quantum Dots Before and After Accelerated Weathering: Toward a Safer-By-Design Strategy.Frontiers in toxicology · 2021Article
- Effects of Oral Exposure to Mn-Doped ZnS Quantum Dots on Intestinal Tract and Gut Microbiota in Mice.Frontiers in physiology · 2021Article
- Nephrotoxicity Evaluation of Indium Phosphide Quantum Dots with Different Surface Modifications in BALB/c Mice.International journal of molecular sciences · 2020Article
- Mixed Mercaptocarboxylic Acid Shells Provide Stable Dispersions of InPZnS/ZnSe/ZnS Multishell Quantum Dots in Aqueous Media.Nanomaterials (Basel, Switzerland) · 2020Article
- Image-guided tumor surgery: The emerging role of nanotechnology.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2020Review
- Revisiting the cytotoxicity of quantum dots: an in-depth overview.Biophysical reviews · 2020Review
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Quantum dot (QD) nanoparticles are highly promising contrast agents and probes for biomedical applications owing to their excellent photophysical properties. However, toxicity concerns about commonly used cadmium-based QDs hinder their translation to clinical applications. In this study we describe the in vivo biodistribution and toxicology of indium-based water soluble QDs in rats following intravenous administration. The biodistribution measured at up to 90 days showed that QDs mainly accumulated in the liver and spleen, with similar elimination kinetics to subcutaneous administration. Evidence for QD degradation in the liver was found by comparing photoluminescence measurements versus elemental analysis. No organ damage or histopathological lesions were observed for the QDs treated rats after 24 h, 1 and 4 weeks following intravenous administration at 12.5 mg/kg or 50 mg/kg. Analysis of serum biochemistry and complete blood counts found no toxicity. This work supports the strong potential of indium-based QDs for translation into the clinic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.