ArticleNeurobiology of disease2018
Discovery of a CLN7 model of Batten disease in non-human primates.
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Article in Neurobiology of disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
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Who cites it
32 citing papers in PubMed, 44 citations in OpenAlex.
- Naturally occurring lysosomal storage disease consistent with neuronal ceroid lipofuscinosis in a group of 5 related captive rhesus macaques (Veterinary pathology · 2026Article
- Generation of a rhesus macaque harboring a multivalent reporter for assessing gene editing outcomes.Scientific reports · 2026Article
- Rhesus macaques with anProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Cage-Side Blood Collections from the Ear Can Be Used for Hematological Evaluations in Japanese Macaques (Macaca fuscata).Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Prodromal pathogenesis of CLN7 Batten Disease revealed by multimodal biomarkers in macaques.bioRxiv : the preprint server for biology · 2025Article
- Long-read structural variant discovery and targeted short read genotyping enables population scale characterization of structural variation in rhesus macaques.Genome biology · 2025Article
- Neuronal ceroid lipofuscinosis: underlying mechanisms and emerging therapeutic targets.Nature reviews. Neurology · 2025Review
- Widefield OCT angiography.Progress in retinal and eye research · 2025Review
- Non-human primates as preclinical models for optic nerve research: advancing insights into their application and potential.Eye (London, England) · 2025Review
- Review
- Wide-field OCT angiography for non-human primate retinal imaging.Biomedical optics express · 2024Article
- Genetic diversity of 1,845 rhesus macaques improves genetic variation interpretation and identifies disease models.Nature communications · 2024Article
- OCT Biomarkers in Ocular CLN2 Disease in Patients Treated With Intraventricular Enzyme Replacement Therapy.Investigative ophthalmology & visual science · 2024Article
- Pathological Functions of Lysosomal Ion Channels in the Central Nervous System.International journal of molecular sciences · 2024Review
- Magnetic resonance brain volumetry biomarkers of CLN2 Batten disease identified with miniswine model.Scientific reports · 2023Article
- Nonhuman primate genetic models for the study of rare diseases.Orphanet journal of rare diseases · 2023Review
- Intravenous functional gene transfer throughout the brain of non-human primates using AAV.Research square · 2023Article
- Retinal organoids derived from rhesus macaque iPSCs undergo accelerated differentiation compared to human stem cells.Cell proliferation · 2022Article
- Aberrant upregulation of the glycolytic enzyme PFKFB3 in CLN7 neuronal ceroid lipofuscinosis.Nature communications · 2022Article
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 1 country.
Jodi L McBrideDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, United States; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, United States. Electronic address: mcbridej@ohsu.edu.
Martha NeuringerDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, United States; Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, OR, United States.
Betsy FergusonDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, United States; Division of Genetics, Oregon National Primate Research Center, Beaverton, OR, United States; Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, United States.
Steven G KohamaDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, United States.
Ian J TaggeAdvanced Imaging Research Center, Oregon Health and Science University, Portland, OR, United States.
Robert C ZweigDivision of Comparative Medicine, Oregon National Primate Research Center, Beaverton, OR, United States.
Laurie M RennerDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, United States.
Trevor J McGillDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, United States; Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, OR, United States.
Jonathan StoddardDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, United States.
Samuel PetersonDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, United States.
Weiping SuDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, United States.
Larry S ShermanDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, United States; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR, United States.
Jacqueline S DomireDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, United States.
Rebecca M DucoreDivision of Comparative Medicine, Oregon National Primate Research Center, Beaverton, OR, United States.
Lois M ColginDivision of Comparative Medicine, Oregon National Primate Research Center, Beaverton, OR, United States.
Anne D LewisDivision of Comparative Medicine, Oregon National Primate Research Center, Beaverton, OR, United States.
Oregon National Primate Research Center · USOregon Health & Science University · US
Funding
Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9MProteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI TED S ACOTT · 1995 to 2026
$19.4MA non-human primate resource for pre-clinical studies of neurodegenerative diseaseR24NS104161 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI SHERMAN, LARRY S. · 2018 to 2020
$1.2MNEI NIH HHS P30 EY010572NIH HHS P51 OD011092NINDS NIH HHS R24 NS104161
Abstract
We have identified a natural Japanese macaque model of the childhood neurodegenerative disorder neuronal ceroid lipofuscinosis, commonly known as Batten Disease, caused by a homozygous frameshift mutation in the CLN7 gene (CLN7
Indexed as
Disease Models, AnimalAnimalsFemaleGene Knockout TechniquesLocomotionMacacaMaleMembrane Transport ProteinsMutation, MissenseNeuronal Ceroid-LipofuscinosesPostural BalancePrimatesVision DisordersMembrane Transport ProteinsMFSD8 protein, humanBatten diseaseCLN7Japanese macaqueLarge animal modelLate infantile neuronal ceroid lipofuscinosisLysosomal storage diseaseMFSD8NeurodegenerationNon-human primateRetinal degeneration
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.