Evidence map›Paper›PMID 30048612›Full record

ArticleNeuron2018

Keeping the Brain Well Fed: The Role of Capillaries and Arterioles in Orchestrating Functional Hyperemia.

Amy R Nippert, Anusha Mishra, Eric A Newman

Registry-linked trialAbstract readComment
In one paragraph

Article in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04733456 (Evaluation of Brain Activity and Oxygenation Using Near-infrared Spectroscopy), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04733456 unknown statusnot on this mapstarted 2021, after this paper: background citation

Evaluation of Brain Activity and Oxygenation Using Near-infrared Spectroscopy (NIRS) in Inflammatory Bowel Disease (IBD) Patients

TypeobservationalSponsorUniversity of CalgaryRan2021 to 2026Enrolled40ConditionsIBD, Maladaptive Behavior Associated With Physical IllnessArmsQuality of life questionnaires, NIRS, Stool Collection, Blood and urine collection
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. TMagnetic resonance in medicine · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Optical imaging and modulation of neurovascular responses.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Amy R NippertDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Anusha MishraKnight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA.
Eric A NewmanDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA. Electronic address: ean@umn.edu.

Funding

Visual TestingP30EY011374 · NEI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI NEWMAN, ERIC A · 1996 to 2019
$8.8M
Regulation of Capillary Blood Flow in the Retina in Health and in Diabetic RetinopathyR01EY026514 · NEI · UNIVERSITY OF MINNESOTA · PI NEWMAN, ERIC A · 2016 to 2020
$1.9M
Glial cell regulation of blood flow in capillariesR01EY026882 · NEI · UNIVERSITY OF MINNESOTA · PI NEWMAN, ERIC A · 2016 to 2020
$1.7M
Training Program in Translational Vision SciencesT32EY025187 · NEI · UNIVERSITY OF MINNESOTA · PI Glenn P Lobo, LINDA K. MCLOON · 2016 to 2026
$1.2M
NEI NIH HHS P30 EY011374NEI NIH HHS R01 EY026514NEI NIH HHS R01 EY026882NEI NIH HHS T32 EY025187
6 · The paper itself

Abstract

Cerebral blood flow increases in regions of increased brain activity. In this issue of Neuron, Rungta et al. (2018) characterize the contribution of different vascular compartments in generating this increase and outline the time course of arteriole and capillary dilation in generating functional hyperemia.

Indexed as

CapillariesHyperemiaArteriolesBrainHumansSynapses

Identifiers

PMID30048612
PMCPMC6980315

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.